Fig. 1

The positions of CpG sites analyzed in BDNF promoter I/exon I (a) and promoter IV/exon IV (b) in various studies. The CpG sites that are significantly differently methylated between cases and controls are marked yellow. The CpG sites, which are part of the significantly different methylated regions, are marked green. TSS is indicated by +1. Additional CpG sites inside of promoter I are highlighted red. The positions of the CpG sites on Infinium 450 K platform are shown. CRE, PasRE, UBE—cis-elements regulating neuronal activity-dependent transcription of BDNF promoters