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Table 3 Methylation levels of BDNF promoters I and IV assessed in patients from open access databases

From: BDNF DNA methylation changes as a biomarker of psychiatric disorders: literature review and open access database analysis

  Patients Controls p value Statistical power
Mean SEM Mean SEM
Database E-GEOD-61107 (Schizophrenia, frontal cortex)
 Promoter I 0.093 0.0026 0.099 0.002 0.09  
 Promoter IV 0.113 0.0028 0.126 0.003 0.0015* 90.6 %
Database E-GEOD-61380 (Schizophrenia, frontal cortex)
 Promoter I 0.105 0.0009 0.108 0.002 0.0023* 30.4 %
 Promoter IV 0.119 0.0012 0.12 0.0016 0.61  
Database E-GEOD-61431 (Schizophrenia, frontal cortex)
 Promoter I 0.123 0.0016 0.128 0.0017 0.13  
 Promoter IV 0.157 0.0018 0.161 0.002 0.22  
Database E-GEOD-61431 (Schizophrenia, cerebellum)
 Promoter I 0.119 0.0027 0.117 0.0018 0.98  
 Promoter IV 0.141 0.003 0.148 0.0029 0.0345 40 %
Database E-GEOD-41826 (MDD, frontal cortex, neurons)
 Promoter I 0.094 0.0007 0.093 0.0008 0.24  
 Promoter IV 0.126 0.0009 0.125 0.001 0.39  
Database E-GEOD-41826 (MDD, frontal cortex, glia)
 Promoter I 0.106 0.001 0.107 0.001 0.30  
 Promoter IV 0.125 0.001 0.126 0.001 0.32  
  1. * Significant after multiple correction