BDNF DNA methylation changes as a biomarker of psychiatric disorders: literature review and open access database analysis

Table 3 Methylation levels of BDNF promoters I and IV assessed in patients from open access databases

	Patients		Controls		p value	Statistical power
	Mean	SEM	Mean	SEM	p value	Statistical power
Database E-GEOD-61107 (Schizophrenia, frontal cortex)
Promoter I	0.093	0.0026	0.099	0.002	0.09
Promoter IV	0.113	0.0028	0.126	0.003	0.0015*	90.6 %
Database E-GEOD-61380 (Schizophrenia, frontal cortex)
Promoter I	0.105	0.0009	0.108	0.002	0.0023*	30.4 %
Promoter IV	0.119	0.0012	0.12	0.0016	0.61
Database E-GEOD-61431 (Schizophrenia, frontal cortex)
Promoter I	0.123	0.0016	0.128	0.0017	0.13
Promoter IV	0.157	0.0018	0.161	0.002	0.22
Database E-GEOD-61431 (Schizophrenia, cerebellum)
Promoter I	0.119	0.0027	0.117	0.0018	0.98
Promoter IV	0.141	0.003	0.148	0.0029	0.0345	40 %
Database E-GEOD-41826 (MDD, frontal cortex, neurons)
Promoter I	0.094	0.0007	0.093	0.0008	0.24
Promoter IV	0.126	0.0009	0.125	0.001	0.39
Database E-GEOD-41826 (MDD, frontal cortex, glia)
Promoter I	0.106	0.001	0.107	0.001	0.30
Promoter IV	0.125	0.001	0.126	0.001	0.32

ISSN: 1744-9081