The role of C957T, TaqI and Ser311Cys polymorphisms of the DRD2 gene in schizophrenia: systematic review and meta-analysis

González-Castro, Thelma Beatriz; Hernández-Díaz, Yazmín; Juárez-Rojop, Isela Esther; López-Narváez, María Lilia; Tovilla-Zárate, Carlos Alfonso; Genis-Mendoza, Alma; Alpuin-Reyes, Mariela

doi:10.1186/s12993-016-0114-z

Table 1 Characteristics of the studies included in this meta-analysis

From: The role of C957T, TaqI and Ser311Cys polymorphisms of the DRD2 gene in schizophrenia: systematic review and meta-analysis

Author	Location	Nos	Number		Genotypes						p for HWE
			Cases	Controls	Cases			Controls			Cases	Controls
			Cases	Controls	A1/A1	A1/A2	A2/A2	A1/A1	A1/A2	A2/A2	Cases	Controls
Taq I
Lafuente [43]	Spain	8	80	188	2	27	51	3	68	117	0.72	0.06
Monakhov [44]	Russia	8	311	364	189	104	18	238	116	10	0.51	0.48
Lafuente [45]	Spain	8	287	243	5	81	157	13	90	184	0.20	0.58
Behravan [17]	Iran	8	38	63	6	21	11	3	39	21	0.01^a	0.52
Dubertret [46]	France	8	103	83	71	29	3	30	40	13	0.98	0.95
Aslan [14]	Turkey	8	99	109	2	97	0	0	106	3	0.00^a	0.00^a
Comings [63]	USA	4	87	69	58	27	2	59	10	0	0.56	0.37
Sanders [65]	USA	4	55	51	38	16	1	36	12	3	0.62	0.20
Campion [79]	France	5	80	80	60	19	1	58	20	2	0.70	0.86
Nöthen [56]	Germany	5	60	60	40	18	2	41	18	1	0.98	0.51
Dollfus [80]	France	6	62	61	41	19	2	11	45	5	0.91	0.00^a
Jonsson [66]	Sweden	6	104	67	70	30	4	45	18	4	0.74	0.24
Dubertret [52]	France	7	50	50	36	13	1	26	21	3	0.88	0.63
Parsons [81]	Spain	8	119	165	92	24	3	93	68	4	0.39	0.04^a
Vijayan [1]	India	8	212	194	102	93	17	88	77	29	0.62	0.08
Srivastava [61]	India	8	222	138	123	93	6	21	96	21	0.02^a	0.00^a

Author	Location	Nos	Number		Genotypes						p for HWE
			Cases	Controls	Cases			Controls			Cases	Controls
			Cases	Controls	CC	CT17	TT	CC	107CT	TT	Cases	Controls
C957T
Jonsson [66]	Sweden	7	173	236	160	12	1	232	4	0	0.23	1.00
Lawford [11]	Australia	6	154	148	48	75	31	27	70	51	0.87	0.73
Hanninen [10]	Finland	7	188	384	59	92	37	104	176	104	0.91	0.102
Kukreti [47]	India	7	101	145	41	38	22	48	64	33	0.03^a	0.23
Hoenicka [19]	Spain	7	131	364	30	61	40	46	174	144	0.48	0.65
Mo [48]	China	8	174	127	61	96	17	29	69	29	0.02^a	0.37
Luo [49]	China	6	466	388	409	55	2	351	37	0	0.70	0.98
Monakhov [44]	Russia	8	311	364	99	152	60	78	183	103	0.90	0.91
Gupta [41]	India	8	254	225	104	112	38	76	120	29	0.41	0.09
Betcheva [12]	Bulgaria	8	255	556	58	128	66	192	253	111	0.89	0.09
Dubertret [46]	France	7	144	142	104	37	3	120	21	1	0.92	0.94
Fan [20]	China	8	421	403	366	52	3	368	34	1	0.43	0.55
Tsutsumi [42]	Japan	9	407	384	367	38	1	341	43	2	0.98	0.64
Arinami [27]	Japan	6	260	312	190	66	4	193	102	17	0.79	0.50
Li [82]	England	7	151	145	112	39	0	118	26	1	0.01^a	0.72
Ohara [32]	Japan	7	170	121	136	34	0	84	36	1	0.37	0.30
Stöber [64]	Germany	7	260	290	207	50	3	236	53	1	0.99	0.21
Breen (1) [83]	England	7	378	292	293	78	7	227	61	4	0.47	0.96
Breen (2)	Scotland	7	151	145	115	33	3	118	26	1	0.71	0.72
Inada [84]	Japan	7	234	94	156	72	6	51	40	3	0.65	0.26
Tallerico [85]	Canada	7	50	51	40	10	0	43	7	1	0.29	0.36
Hori [39]	Japan	7	241	201	162	71	8	142	54	5	0.94	0.96
Himei [40]	Japan	7	190	103	118	69	3	71	27	5	0.06	0.30
Dubertret [52]	France	8	103	83	83	19	1	43	33	7	0.93	0.79
Kapman [86]	Finland	7	93	94	86	7	0	88	6	0	0.60	0.65
Parsons [81]	Spain	8	108	153	88	20	0	135	18	0	0.59	0.28
Lafuente [45]	Spain	8	243	291	208	33	2	235	54	2	0.63	0.75
Luu [67]	China	8	211	201	165	44	2	163	34	4	0.60	0.24
Sanders [57]	Europe	8	1870	2002	1495	354	21	1643	341	18	0.99	0.94
Cordeiro [68]	Brazil	8	229	733	183	38	8	498	206	29	0.00^a	0.20
Srivastava [61]	India	8	233	224	161	65	7	172	48	4	0.81	0.75
Kurt [87]	Turkey	8	73	60	45	26	2	34	25	1	0.71	0.26
Saiz [88]	Spain	8	272	404	181	76	15	301	98	5	0.08	0.51
Xiao [69]	China	8	120	100	96	22	2	68	28	4	0.62	0.51

^aSignificant p value

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ISSN: 1744-9081

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