Frontal dysconnectivity in 22q11.2 deletion syndrome: an atlas-based functional connectivity analysis

Table 3 Differential functional connectivity between 22q11DS and controls

Functional connection (ROI–ROI) 22q11DS vs controls	Lobar-level connections	t value	p value, corr	22q11DS^a	controls^a
Right precentral–right posterior cingulate	Frontal–frontal	3.59	0.038	0.232	0.067
Right superior frontal–left posterior cingulate	Frontal–frontal	3.22	0.025	0.230	0.036
Right superior frontal–right posterior cingulate	Frontal–frontal	3.23	0.025	0.411	0.212
Right pars orbitalis–left cuneus	Frontal–occipital	3.79	0.019	0.011	− 0.187
Right pars orbitalis––right cuneus	Frontal–occipital	3.44	0.022	0.021	− 0.146
Right pericalcarine–left paracentral	Frontal–occipital	3.42	0.033	− 0.013	− 0.173
Right pericalcarine–right postcentral	Frontal–occipital	3.27	0.035	− 0.013	− 0.159
Right precuneus–right caudal middle frontal	Frontal–parietal	4.04	0.008	0.281	0.054
Left Precuneus–right pars orbitalis	Frontal–parietal	3.42	0.033	− 0.109	− 0.313
Right precuneus–right pars orbitalis	Frontal–parietal	3.23	0.04	0.014	− 0.174
Left precuneus–right superior frontal	Frontal–parietal	4.06	0.008	0.110	− 0.113
Right precuneus–right superior frontal	Frontal–parietal	3.30	0.04	0.289	0.092
Right superior frontal–right lateral orbito frontal gyrus	Frontal–frontal	− 3.37	0.025	0.102	0.312
Right pericalcarine–left pericalcarine	Occipital–occipital	− 3.98	0.01	1.254	1.488
Left superior parietal–left fusiform	Parietal–temporal	− 3.55	0.021	0.208	0.382
Left superior parietal–left inferior temporal gyrus	Parietal–temporal	− 3.63	0.021	0.156	0.379

Functional connections displayed within this table represent connections that were significantly different between 22q11DS and controls, FDR-corrected, p < 0.05
^aMean functional connectivity values reported for each study group

ISSN: 1744-9081