Fig. 1

Progression of motor impairment in Elovl5^−/− mice administered with a PUFA precursors diet. Bar graphs showing the number of errors at different ages (from 1 to 10th month of age) for wild type and Elovl5^−/− mice. Elovl5^−/− mice undergo a great worsening of motor coordination across months, while wild type mice, after the first month of age, show an almost unchanged mean number of errors with age (****P < 0.0001, Two-way ANOVA; n = 23 wild type mice, n = 18 Elovl5^−/− mice). Values are mean ± S.E.M