Fig. 2

Administration of a complete PUFA diet since birth on Elovl5 ^−/− mice slows down motor impairment. A Scheme of diet administration: one group composed of Elovl5^−/− (n = 18) and wild type mice (n = 17) received a diet providing them with both Elovl5 substrates and downstream products from birth (complete PUFA diet), while the other group of Elovl5^−/− (n = 38) and wild type mice (n = 38) received only PUFA precursors from birth (PUFA precursors only). B, C Bar graphs showing errors committed traversing the experimental apparatus at 1 month of age for wild type and Elovl5^−/−mice who received the two different diets (for wild type mice: *P < 0.05; for Elovl5^−/−mice P > 0.05, Unpaired Student’s t-test). D, E Motor performances at 6 months of age for Elovl5^−/−mice and wild type littermates receiving the two different diets from birth (for wild type mice: **P < 0.01; for Elovl5^−/−mice *P < 0.05, Unpaired Student’s t-test). F, G Motor performances at 8 months of age for Elovl5^−/− mice and control littermates compared to genotype matched PUFA precursors mice (P < 0.05, Unpaired Student’s t-test). Values are mean ± S.E.M