Fig. 4

Administration of a complete PUFA diet on Elovl5^−/− mice in late adulthood does not ameliorate motor deficits. A Schematic representation of the experimental design. One group composed of 10 months old Elovl5^−/− (n = 8) and wild type mice (n = 16) received the complete PUFA diet since 10 months of age and the motor performance was checked after two months of administration. B, C Mean number of errors committed traversing the experimental apparatus for both wild type and Elovl5^−/− mice at 10 (white bars) and 12 months (grey bars). As shown, the complete diet administered in late adulthood fails to rescue motor coordination impairment of Elovl5^−/− mice (for both wild type and Elovl5^−/− mice: P > 0.05, Unpaired Student’s t-test). Values are mean ± S.E.M