Fig. 10
From: Inhibition of NLRP1 inflammasome improves autophagy dysfunction and Aβ disposition in APP/PS1 mice
NLRP1-siRNA treatment reverse AMPK/mTOR pathway mediated autophagy dysfunction in APP/PS1 mice (Western blot). A The bands of AMPK, p-AMPK, mTOR, p-mTOR and β-actin; B The relative expression of p-AMPK/AMPK over NS; C The relative expression of p-mTOR/mTOR over NS. D The bands of Beclin1, LC3, P62 and β-actin; E The relative expression of Beclin1 over NS; F The relative expression of LC3II/LC3I over NS; G The relative expression of P62 over NS. Results are expressed as mean ± SD, n = 4. *P < 0.05, **P < 0.01 vs NS group