Fig. 6
From: Inhibition of NLRP1 inflammasome improves autophagy dysfunction and Aβ disposition in APP/PS1 mice
NLRP1-siRNA treatment alleviates neuronal damage in APP/PS1 mice. A The results of H&E staining (Cortex 200× , bar = 50 μm; 400× , bar = 20 μm). The black arrow indicates neuronal damage caused by Aβ deposition; The red arrow indicates Aβ plaque. B The results of Nissl staining in the cortex and hippocampus CA1 (400× , bar = 20 μm); (C–D) The mean density of Nissl bodies in the cortex and hippocampus CA1. E The bands of β-Gal, PSD95 and β-actin (Western blot); F The relative expression of β-Gal over NS; G The relative expression of PSD95 over NS. Results are expressed as mean ± SD, n = 4. *P < 0.05, **P < 0.01 vs NS group