Fig. 2

Impaired working memory in mice at 7 months after intra-hippocampal cis P-tau injection. The percentage of spontaneous alternation (A) and the percentage of time spent in center point (B) significantly decreased at 7 months after intra-hippocampal cis P-tau injection in cis P-tau compared to control group. There was no significant difference in total distance between cis P-tau and control groups (C). Color maps depict the mean spontaneous alternation across all animals in each group, showing the percent time in each arm during the whole eight-min test duration (D). All data represents mean ± SEM. **P < 0.01 and *** P < 0.001 compared to the control group