Interaction between childhood trauma experience and TPH2 rs7305115 gene polymorphism in brain gray matter volume

Table 3 Significant brain subregions distribution that showed main effects and interaction of genotype and CTQ score in GMV and behaviour statistics

	Brain subregions	B	p
Main effect of CTQ score	RPhG_A28/34	1.487	0.027
	LSTG_A41/42	− 7.263	0.043
	LSTG_A38l	7.319	0.021
	RITG_A20r	1.596	0.042
	RPhG_A35/36r	2.769	0.047
	RcpSTS	3.507	0.019
	LPcun_A5m	0.585	0.015
	LPcun_A5m31	12.149	0.039
	RPcun_A5m31	9.747	0.032
Main effect of genotype	RITG_A37elv	28.236	0.046
	RPPTha	19.704	0.001
	RITG_A20il	90.775	0.024
	RPhG_ A35/36c	23.376	0.044
Interaction of genotype × CTQ score	ROrG_A14m	− 5.124	0.041
	LPrG_A4tl	− 4.114	0.048
	RITG_A20iv	− 1.189	0.012
	LcpSTS	3.804	0.027
	LCG_A32sg	− 7.239	0.048
	LBG_vCa	3.428	0.048
	RBG_dCa	4.167	0.019
	RPPTha	− 0.156	0.029
	ROtha	0.165	0.048
	Behaviour scores
Interaction of genotype × CTQ score	STAI(S)	− 0.089	0.000
	STAI(T)	− 0.138	0.003
	TPQ(NA)	− 0.068	0.021

CTQ: Childhood Trauma Questionnaire; STAI (S): state inventory of Spielberger’s State-Trait Anxiety Inventory; STAI (T): trait inventory of Spielberger’s State-Trait Anxiety Inventory; TPQ (NA): the harm avoidance questionnaire of the Tridimensional Personality Questionnaire; GMV: gray matter volume; RPhG_A28/34: right Parahippocampal Gyrus area 28/34 (EC, entorhinal cortex); LSTG_A41/42: left Superior Temporal Gyrus area 41/42; LSTG_A38l: left Superior Temporal Gyrus lateral area 38; RITG_A20r: right Inferior Temporal Gyrus rostral area 20; RPhG_A35/36r: right Parahippocampal Gyrus rostral area 35/36; RcpSTS: right caudoposterior Superior Temporal Sulcus; LPcun_A5m: left Precuneus medial area 5(PEm); LPcun_A5m31: left Precuneusarea 31 (Lc1); RPcun_A5m31: right Precuneus area 31 (Lc1); RITG_A37elv: right Inferior Temporal Gyrus extreme lateroventral area 37; RITG_A20il: right Inferior Temporal Gyrus intermediate lateral area 20; RPhG_ A35/36c: right Parahippocampal Gyrus caudal area 35/36; ROrG_A14m: right Orbital Gyrus medial area 14; LPrG_A4tl: left Precentral Gyrus area 4(trunk region); RITG_A20iv: right Inferior Temporal Gyrus intermediate ventral area 20; LcpSTS: left caudoposterior Superior Temporal Sulcus; LCG_A32sg: left Cingulate Gyrus subgenual area 32; LBG_vCa: Left Basal Ganglia ventral caudate; RBG_dCa: Right Basal Ganglia dorsal caudate; RPPTha: right Posterior Parietal thalamus; ROtha: right Occipital thalamus
^*B stands the beta value

ISSN: 1744-9081