Fig. 4

A At day 3, day 4 or day 5, the rats in the IE group had the longer latency to platform than the rats in the FCA-IE group. At day5, the rats in the IE group had the longer latency to platform than the rats in the TAT-Gap19-IE group. IE vs. FCA-IE group: ^*p < 0.05; IE vs. TAT-Gap19-IE group: ^#p < 0.05; IE vs. Sham group: ^&p < 0.05, ^&&p < 0.01. B The rats in the FCA-IE or TAT-Gap19-IE group spent more time in target quadrant C compared with the rats in the IE group. ^*p < 0.05. C The rats in the FCA-IE or TAT-Gap19-IE group had more target crossing times when compared with the rats in the IE group. ^*p < 0.05, ^**p < 0.01. D At day 5, the rats in the IE group had the longer latency to platform than the rats in the siRNA Cx43-IE group. IE vs. siRNA Cx43-IE group: ^**p < 0.01; IE vs. Sham group: ^&p < 0.05, ^&&p < 0.01. E The rats in the siRNA Cx43-IE group spent more time in target quadrant C compared with the rats in the IE group. ^**p < 0.01, ^***p < 0.001. F The rats in the siRNA Cx43-IE group had more target crossing times when compared with the rats in the IE group. ^*p < 0.05, ^**p < 0.01. G The rats in the siRNA Cx43-IE group had lower expression of Cx43 mRNA when compared with the rats in the IE or nontargeted siRNA-IE group. ^*p < 0.05,^**p < 0.01.Data represents means ± SD, n = 6