Fig. 2

Diurnal rhythm of 24 h registered activity in actimeter (total counts A and distance B) in the sham- and pin-operated rats aged 3-, 14- and 18 months. The two phases (Light and Dark) are shown with open and black rectangles above the figures. Data are presented as mean ± SEM, n = 8. Three-way ANOVA showed a main Age effect for total locomotor activity [F2,71 = 4.92, p = 0.01], Surgery effect [F2,71 = 3.82, p = 0.026] and Phase effect [F2,71 = 33.42, p < 0.001]. ^#p < 0.05; ^##p < 0.01; ^###p < 0.001 Dark phase compared to the Light phase; ***p = 0.0012, 18 month-old sham rats compared to the matched 14-month-old rats; ^op = 0.029, 3 month old pin rats compared to the matched sham rats. A *p = 0.012, 18 month old sham rats compared to 14 month-old rats B