Fig. 5
The effect of pinealectomy on total distance A, total arms entrances B, distance in open arms C, time in the open arms D, measured in the EPM test, in 3-, 14- and 18 month-old rats measured. Data are presented as mean ± SEM. A main Age effect was indicated for total distance [F2,50 = 46.817, p < 0.001], total arms entrances [F2,50 = 17.427, p < 0.001], distance in open arms [F2,50 = 8.725, p < 0.001], time in open arms [F2,50 = 4. 011, p = 0.025]. The main effect of Surgery was significant for distance in open arms [F1,50 = 4.436, p = 0.041], and time in open arms [F1,50 = 4.112, p = 0.047]. Age x Surgery interaction was detected in total arms entrances [F2,50 = 7.280, p = 0.002], and time in open arms [F2.50 = 6.092, p = 0.005]. ***p < 0.001, 18-month-old sham rats compared to 3 month-old sham rats; *p = 0.014, 18 month-old sham rats compared to 14 month-old sham rats; **p = 0.008, 14 month-old sham rats compared to 3 month-old sham rats; **p = 0.005, 3 month-old pin rats compared to matched sham rats A; *p = 0.045, 18-month-old sham rats compared to 3 month-old sham rats; *p = 0.028, 14 month-old sham rats compared to 3 month-old sham rats; ***p < 0.001, 3-month-old pin rats compared to matched sham rats B; p = 0.01, 18 month-old sham rats compared to 3 month-old sham rats; *p = 0.013, 3 month-old pin rats compared to matched sham ratsp = 0.0126, 18-month-old pin rats compared to matched sham rats C; *p = 0.025, 14-month-old sham rats compared to 3 month-old sham rats; **p = 0.009, 18-month-old sham rats compared to 14 month-old sham rats; ***p = 0.001, 3 month-old pin rats compared to matched sham rats; *p = 0.045, 18 month-old pin rats compared to matched sham rats D