Fig. 6

The effect of pinealectomy on latency to cross in the lid compartment A and time spent in the lid compartment B, measured in the light–dark test, in 3-, 14- and 18 month-old rats. Two-way ANOVA showed a main Age effect [F2,46 = 6.668, p = 0.003]; [F2,46 = 3.242, p = 0.049], Surgery effect [F1,46 = 12.107, p = 0.001], [F1,46 = 14.754, p < 0.001] and Age x Surgery interaction [F2,46 = 6.839, p = 0.003], [F2,46 = 3.436, p = 0.042] for the latency to cross in the lid compartment and time spent in the lid compartment. Data are presented as mean ± SEM. *p < 0.001, 18 month-old sham rats compared to 3-month-old sham rats; *p < 0.001, 18-month-old sham rats compared to 14 month-old sham rats; ^*p = 0.041, 3 month-old pin rats compared to matched sham rats; ^*p < 0.001, 18 month-old pin rats compared to matched sham rats A; ^**p = 0.003, 3 month-old pin rats compared to matched sham rats; ^**p = 0.004, 18 month-old pin rats compared to matched sham rats B