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Table 2 Effect of pinealectomy, induced in 3-, 14- and 18 month-old rats, on plasma corticosterone level (ng/ml) in basal condition (0ʹ), 10 min (10ʹ) and 120 min after stress procedure (forced swimming for 5 min)

From: The role of melatonin deficiency induced by pinealectomy on motor activity and anxiety responses in young adult, middle-aged and old rats

Time

Corticosterone (ng/ml)

0ʹ

10ʹ

120ʹ

Group

 Sham 3 m

9.042 ± 0.126

15.44 ± 1.925*

5.118 ± 0.199#

 Pin 3 m

8.860 ± 0.223

15.38 ± 1.520*

5.188 ± 0.163#

 Sham 14 m

9.114 ± 0.348

16.05 ± 0.975*

5.281 ± 0.137#

 Pin 14 m

8.781 ± 0.263

16.60 ± 1.731*

5.221 ± 0.137#

 Sham 18 m

9.362 ± 0.239+

17.24 ± 1.364*

5.331 ± 0.124#

 Pin 18 m

15.09 ± 1.78o

17.38 ± 1.668

5.284 ± 0.128#

  1. Data are given as mean ± SEM and analyzed by three-way ANOVA followed by Bonferroni post hoc test (n = 6–8). *p ≤ 0.05 in comparison with 0ʹ within the same group; + p ≤ 0.05 in comparison with the 3 month-old sham rats; #p ≤ 0.05 in comparison with 10ʹ; op ≤ 0.05 in comparison with the matched sham group at the same age
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Behavioral and Brain Functions

ISSN: 1744-9081

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