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Table 1 The percent decrease in amplitude from baseline of P2 and N2 components in the various brain areas of adult male WKY rats following a single injection of 0.6, 2.5, and 10.0 mg/kg MPD (i.p.).

From: Dose-response characteristics of methylphenidate on locomotor behavior and on sensory evoked potentials recorded from the VTA, NAc, and PFC in freely behaving rats

Component

Brain Area

0.6 mg/kg MPD

2.5 mg/kg MPD

10.0 mg/kg MPD

P2

VTA

15.3 ± 5.5%

38.8 ± 6.2%

41.3 ± 10.6%

 

NAc

12.5 ± 9.2%

20.5 ± 2.7%

51 ± 5.9%

 

PFC

-11 ± 2.2%

34.3 ± 4.7%

43 ± 8.7%

N2

VTA

21.8 ± 5.9

34.8 ± 6.7%

55 ± 6 %

 

NAc

23.5 ± 5.9%

53.5 ± 3.2%

60 ± 2.4%

 

PFC

29.5 ± 7.4

65 ± 6

76.5 ± 2.7