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Table 2 The effect of a single administration of 0.6, 2.5, and 10.0 mg/kg MPD on the attenuation in amplitude from baseline of P2 and N2 components during 10, 20, 30, and 40 min post-injection.

From: Dose-response characteristics of methylphenidate on locomotor behavior and on sensory evoked potentials recorded from the VTA, NAc, and PFC in freely behaving rats

  

VTA

NAc

PFC

 

Time post-injection

0.6 mg/kg

2.5 mg/kg

10.0 mg/kg

0.6 mg/kg

2.5 mg/kg

10.0 mg/kg

0.6 mg/kg

2.5 mg/kg

10.0 mg/kg

P2

10 min

11.0

57.0

58.0

21.0

17.0

56.0

-9.0

21.0

63.0

 

20 min

3.0

36.0

57.0

-12.0

28.0

61.0

-11.0

38.0

52.0

 

30 min

29.0

32.0

37.0

10.0

16.0

53.0

-7.0

43.0

28.0

 

40 min

18.0

30.0

13.0

31.0

21.0

34.0

-17.0

35

29

N2

10 min

16.0

51.0

68

34.0

62.0

64.0

37.0

75.0

82.0

 

20 min

4.0

40.0

61.0

11.0

48.0

61.0

9.0

71.0

78.0

 

30 min

37.0

26.0

50.0

16.0

55.0

62.0

43.0

66.0

77.0

 

40 min

30.0

22.0

41.0

33.0

49.0

53.0

29.0

48.0

69.0