Skip to main content

Table 2 SCZ-associated variants on chromosome 2-22 and the chromosome X that could meet or do not meet the criterion in the Top 45 genes at the SZGene Database (Updated Dec 23, 2011)

From: Paradox of schizophrenia genetics: is a paradigm shift occurring?

Genes and SNPs

Location

Allele (min/maj)

m A

m U

OR

d

IL1B

2q13

     

rs16944

 

T/C*

0.6289 (N=1,718)

0.6066 (N=2,157)

1.11

0.022

ZNF804A

2q32.1

     

rs1344706

 

G/T*

0.6357 (N=6,487)

0.6032 (N=11,478)

1.14

0.033

CCKAR

4p15.2

     

rs1800857

 

C*/T

0.1666 (N=105)

0.1559 (N=93)

1.32

0.008

GABARB2

5q34

     

rs1816072

 

C/T*

0.6404 (N=1,129)

0.5935 (N=995)

1.22

0.047

rs194072

 

C/T*

0.8685 (N=1,137)

0.8466 (N=991)

1.20

0.022

rs6556547

 

T/G*

0.9444 (N=774)

0.9226 (N=620)

1.43

0.022

DTNBP1

6p23

     

rs3213207

 

G/A*

0.8891 (N=8,377)

0.8758 (N=8,886)

1.11

0.013

rs1474605

 

G/A*

0.8000 (N=3,710)

0.7858 (N=3,588)

1.09

0.014

HIST1H2BJ

6p22.1

     

rs6913660

 

A/C*

0.8927 (N=10,065)

0.8801 (N=34,098)

1.15

0.013

PRSS16

6p22.1

     

rs6932590

 

C/T*

0.7943 (N=7,177)

0.8058 (N=28,270)

1.16

-0.012

rs13219354

 

C/T*

0.9088 (N=6,478)

0.9020 (N=27,224)

1.20

0.007

PGBD1

6p22.1

     

rs13211507

 

C/T*

0.9518 (N=9,774)

0.9387 (N= 33,694)

1.23

0.013

RPP21

6p21.33

     

rs3130375

 

A/C*

0.9018 (N=2,799)

0.8634 (N=3,082)

1.41

0.038

NOTCH4

6p21.32

     

rs3131296

 

A/G*

0.8912 (N=7,156)

0.8892 (N=28,312)

1.20

0.002

rs2071287

 

A/G*

0.6858 (N=2,511)

0.6463 (N=2,556)

1.19

0.039

MDGA1

6p21.2

     

rs11759115

 

C/T*

0.8639 (N=1,874)

0.8379 (N=2,582)

1.23

0.026

rs12191311

 

T*/C

0.3619 (N=1,879)

0.3555 (N=2,605)

1.12

0.006

rs7769372

 

T*/C

0.2328 (N=1,915)

0.1885 (N=2,576)

1.18

0.044

AH1

6q23.3

     

rs2064430

 

T*/C

0.5672 (N=2,796)

0.5296 (N=13,494)

1.13

0.038

rs11154801

 

A/C*

0.6633 (N=3,298)

0.6576 (N=14,805)

1.09

0.006

C6orf217

6q23.3

     

rs10223338

 

T/C*

0.7158 (N=2,797)

0.6975 (N=13,522)

1.12

0.018

rs1475069

 

C*/A

0.7205 (N=3,276)

0.6976 (N=14,639)

1.14

0.023

rs9321521

 

A/G*

0.6755 (N=2,784)

0.6642 (N=13,311)

1.12

0.011

RELN

7q22.2

     

rs7341475

 

A/G*

0.8327 (N=3,315)

0.8110 (N=8,042)

1.14

0.022

rs262355

 

A*/T

0.3852 (N=1,128)

0.3563 (N=1,848)

1.14

0.029

PPP3CC

8p21.3

     

rs2461491

 

A*/G

0.4469 (N=6,287)

0.4353 (N=6,200)

1.07

0.015

rs10108011

 

G*/A

0.3657 (N=4,304)

0.3488 (N=4,465)

1.09

0.0170

SLC18A1

8p21.3

     

rs2270641

 

C*/A

0.3182 (N=759)

0.2802 (N=885)

1.63

0.038

NRG1

8p12

     

rs10503929

 

C/T*

0.8342 (N=3,256)

0.8118 (N=4,181)

1.14

0.022

GWA_10q26.13

10q26.11

     

rs17101921

 

A*/G

0.06667 (N=7,447)

0.04318 (N=13,039)

1.28

0.023

DRD4

11p15.5

     

rs4646984

 

S/L*

0.7750 (N=1,558)

0.7292 (N=1,499)

1.27

0.046

rs1800955

 

C*/T

0.4235 (N=2,450)

0.4018 (N=2,506)

1.12

0.022

TPH1

11p15.1

     

rs1800532

 

A*/C

0.4752 (N=2,416)

0.4299 (N=3,623)

1.16

0.045

rs1799913

 

A*/C

0.4546 (N=1,323)

0.4171 (N=2,201)

1.14

0.038

GWA_11p14.1

11p14.1

     

rs1602565

 

C*/T

0.1346 (N=5,475)

0.1152 (N=10,845)

1.19

0.019

DRD 2

11q23.1

     

rs6277

 

C*/T

0.4968 (N=3,156)

0.4527 (N=3,960)

1.40

0.044

rs6275

 

T*/C

0.3106 (N=2,436)

0.2927 (N=2,918)

1.15

0.018

rs1801028

 

G*/C

0.0245 (N=4,304)

0.0207 (N=5,920)

1.33

0.004

NRGN

11q24.2

     

rs12807809

 

C/T*

0.8403 (N=7,213)

0.8190 (N=28,490)

1.15

0.021

OPCML

11q25

     

rs3016384

 

T/C*

0.5374 (N=5,491)

0.5141 (N=10,900)

1.10

0.023

GRIN2B

12p13.1

     

rs1019385

 

T/G*

0.5604 (N=687)

0.4885 (N=650)

1.33

0.072

DAO

12q24.11

     

rs4623951

 

C/T*

0.7038 (N=1,509)

0.6788 (N=1,521)

1.14

0.025

HTR2A

13p14.13

     

rs6311

 

A*/G

0.4441 (N=2,594)

0.4115 (N=2,869)

1.21

0.033

DAOA

13q33.3

     

rs778293

 

G*/A

0.3149 (N=2,899)

0.2770 (N=3,218)

1.18

0.038

rs3916971

 

T/C*

0.5622 (N=844)

0.5211 (N=922)

1.19

0.041

AKT1

14q32.33

     

rs3803300

 

A*/G

0.1068 (N=1,301)

0.1039 (N=1,424)

1.36

0.003

GWA_16p13.12

16p13.12

     

rs7192086

 

T*/A

0.2701 (N=7,179)

0.2456 (N=12,623)

1.12

0.025

RPGRIP1L

16q12.2

     

rs9922369

 

A*/G

0.0403 (N=6,494)

0.0336 (N=11,449)

1.32

0.007

HP

16q22.3

     

Hp_1/2

 

1/2*

0.6208 (N=1,300)

0.5911 (N=1,976)

1.14

0.030

SRR

17p13.3

     

rs408067

 

G*/A

0.3166 (N=1,145)

0.2779 (N=1,146)

1.22

0.039

TCF4

18q21.2

     

rs9960767

 

C*/A

0.0514 (N=9,755)

0.0467 (N=33,648)

1.23

0.005

APOE

19q13.32

     

e4-allele

 

E2/3/4*

0.1391 (N=1,596)

0.1139 (N=3,038)

1.16

0.025

COMT

22q11.21

     

rs737865

 

C/T*

0.6916 (N=7,397)

0.6803 (N=10,411)

1.06

0.011

rs4818

 

G*/C

0.3503 (N=177)

0.3081 (N=99)

1.05

0.042

  1. On chromosomes 2-22 and the chromosome X, 17 variants at 15 loci (CCKAR, DTNBP1, HIST1H2BJ, PRSS16, PGBD1, NOTCH4, MDGA1, AH1, C6orf217, PPP3CC, DRD 2, AKT1, RPGRIP1L, TCF4, COMT) could meet the criterion under the assumption that the mutation rates at those loci are near the upper limit in the autosomes and the X chromosome. 15 protective genes (IL1B, ZNF804A, GABARB2, RELN, GWA_10q26.13, DRD4, TPH1, GWA_11p14.1, GRIN2B, DAO, HTR2A, DAOA, GWA_16p13.12, SRR, APOE) are located on 2q, 5q, 7q, 10q, 11p, 12p, 12q, 13p, 13q, 16p, 17p, and 19q, where no SCZ-associated variants that could meet the criterion are located
  2. *alleles associated with SCZ.