Jablensky AV: Schizophrenia: the Epidemiological Horizon. Schizophrenia. Edited by: Hirsch SR, Weinberger DR. 1995, London: Blackwell Science, 206-252.
Google Scholar
Huxley J, Mayr E, Osmond H, Hoffer A: Schizophrenia as a genetic morphism. Nature. 1964, 204: 220-221. 10.1038/204220a0.
Article
CAS
PubMed
Google Scholar
Crow TJ: A Darwinian approach to the origin of psychosis. Brit J Psychiatry. 1995, 167: 12-25. 10.1192/bjp.167.1.12.
Article
CAS
Google Scholar
Brüne M: Schizophrenia - an evolutionary enigma?. Neurosci Biobehav Rev. 2004, 28: 41-53. 10.1016/j.neubiorev.2003.10.002.
Article
PubMed
Google Scholar
Keller CK, Miller G: Resolving the paradox of common, harmful, heritable mental disorders: Which evolutionary genetic models work best?. Behav Brain Sci. 2006, 29: 385-452.
PubMed
Google Scholar
Bassett AS, Bury A, Hodgkinson KA, Honer WG: Reproductive fitness in familial schizophrenia. Schizophr Res. 1996, 21: 151-160. 10.1016/0920-9964(96)00018-7.
Article
PubMed Central
CAS
PubMed
Google Scholar
McGrath JJ, Hearle J, Jenner L, Plant K, Drummond A, Barkla JM: The fertility and fecundity of patients with psychoses. Acta Psychiatr Scand. 1999, 99: 441-446. 10.1111/j.1600-0447.1999.tb00990.x.
Article
CAS
PubMed
Google Scholar
Haukka J, Suvisaari J, Lonnqvist J: Fertility of patients with schizophrenia, their siblings, and the general population: a cohort study from 1950 to 1959 in Finland. Am J Psychiatry. 2003, 160: 460-463. 10.1176/appi.ajp.160.3.460.
Article
PubMed
Google Scholar
Svensson AC, Lichtenstein P, Sandin S, Hultman CM: Fertility of first-degree relatives of patients with schizophrenia: A three generation perspective. Schizophr Res. 2007, 91: 238-245. 10.1016/j.schres.2006.12.002.
Article
PubMed
Google Scholar
Bundy H, Stahl D, McCabe JH: A systemic review and meta-analysis of the fertility of patients with schizophrenia and their unaffected relatives. Acta Psychiatr Scand. 2011, 123: 98-106. 10.1111/j.1600-0447.2010.01623.x.
Article
CAS
PubMed
Google Scholar
Doi N, Hoshi Y, Itokawa M, Usui C, Yoshikawa T, Tachikawa H: Persistence criteria for susceptibility genes for schizophrenia – a discussion from an evolutionary view point. PLoS One. 2009, 4 (11): e7799-10.1371/journal.pone.0007799.
Article
PubMed Central
PubMed
CAS
Google Scholar
Sigurđardóttir S, Helgason A, Gulcher JR, Stefansson K, Donnely P: The mutation rate in the human mtDNA control region. Am J Hum Genet. 2000, 66: 1599-1609. 10.1086/302902.
Article
Google Scholar
Vogel F, Motulsky AG: Human genetics: problems and approaches. 1997, Berlin: Springer
Book
Google Scholar
Nachman MW, Crowell SL: Estimate of the mutation rate per nucleotide in humans. Genetics. 2000, 156: 297-304.
PubMed Central
CAS
PubMed
Google Scholar
Marchbanks RM, Mulcrone J, Whatley SA: Aspects of oxidative metabolism in schizophrenia. Brit J Psychiatry. 1995, 167: 293-298. 10.1192/bjp.167.3.293.
Article
CAS
Google Scholar
Ben-Shachar D: Mitochondrial dysfunction in schizophrenia: a possible linkage to dopamine. J Neurochemistry. 2002, 83: 1241-1251. 10.1046/j.1471-4159.2002.01263.x.
Article
CAS
Google Scholar
Wood SJ, Yücel M, Pantelis C, Berk M: Neurobiology of schizophrenia spectrum disorders: the role of oxidative stress. Ann Acad Med Singapore. 2009, 2009 (38): 396-401.
Google Scholar
Bitanihirwe BKY, Woo TUW: Oxidative stress in schizophrenia: an integrated approach. Neurosci Biobehav Rev. 2011, 35: 878-893. 10.1016/j.neubiorev.2010.10.008.
Article
PubMed Central
CAS
PubMed
Google Scholar
Allen NC, Bagade S, McQueen MB, Ioannidis JP, Kavvoura FK, Khoury MJ, Tanzi RE, Bertram L: Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the szgene database. Nat Genet. 2008, 40: 827-834. 10.1038/ng.171.http://www.schizophreniaforum.org/res/szgene/default.asp,
Article
CAS
PubMed
Google Scholar
Need AC, Ge D, Weale ME, Maia J, Feng S, Heinzen EL, Shianna KV, Yoon W, Kasperaviciūte D, Gennarelli M, Strittmatter WJ, Bonvicini C, Rossi G, Jayathilake K, Cola PA, McEvoy JP, Keefe RS, Fisher EM, St Jean PL, Giegling I, Hartmann AM, Möller HJ, Ruppert A, Fraser G, Crombie C, Middleton LT, St Clair D, Roses AD, Muglia P, Francks C, Rujescu D, Meltzer HY, Goldstein DB: A genome-wide investigation of SNPs and CNVs in schizophrenia. PLoS Genet. 2009, 5 (2): e1000373-10.1371/journal.pgen.1000373.
Article
PubMed Central
PubMed
CAS
Google Scholar
U.S. Census Bureau: World POPClock Projection.http://www.census.gov/population/popclockworld.html,
Saha S, Chant D, Welham J, McGrath J: A systemic review of the prevalence of schizophrenia. PLoS Med. 2005, 2: 413-433.
Article
Google Scholar
Andreyev AY, Kushnareva YE, Starkov AA: Mitochondrial metabolism of reactive oxygen species. Biochemistry (Moscow). 2005, 70: 200-214. 10.1007/s10541-005-0102-7.
Article
CAS
Google Scholar
Esposito LA, Melov S, Panov A, Cottrell BA, Wallace DC: Mitochondrial disease in mouse results in increased oxidative stress. Proc Natl Acad Sci USA. 1999, 96: 4820-4825. 10.1073/pnas.96.9.4820.
Article
PubMed Central
CAS
PubMed
Google Scholar
Senoo-Matsuda N, Yasuda K, Tsuda M, Ohkubo T, Yoshimura S, Nakazawa H, Hartman PS, Ishii N: A defect in the cytochrome b large subunit in complex II causes both superoxide anion overproduction and abnormal energy metabolism in Caenorhabditis elegans. J Biol Chem. 2001, 276: 41553-4155819. 10.1074/jbc.M104718200.
Article
CAS
PubMed
Google Scholar
Hayashi M: A study on schizophrenia. Psychiatr Neurol Japonica. 1950, 51: 193-253.
Google Scholar
Utena H, Ezoe T: Studies on the carbohydrate metabolism in brain tissues of schizophrenic patients. II. Report. Psychiatr Neurol Japonica. 1951, 52: 216-233.
Google Scholar
Takahashi Y: An enzymological study on brain tissue of schizophrenic patients. Carbohydrate metabolism. Folia Psychiatr Neurol Jpn. 1953, 7: 214-269.
Google Scholar
Stabeneau JR, Pullin W, Moshe RLR, Froman C, Friedhoff AJ, Turner W: Study of monozygotic twins discordant for schizophrenia. Some biologic variables. Arch Gen Psychiatry. 1969, 20: 145-158. 10.1001/archpsyc.1969.01740140017002.
Article
Google Scholar
Prabakaran S, Swatton JE, Ryan MM, Huffaker SJ, Huang JT, Griffin JL, Wayland M, Freeman T, Dudbridge F, Lilley KS, Karp NA, Hester S, Tkachev D, Mimmack ML, Yolken RH, Webster MJ, Torrey EF, Bahn S: Mitochondrial dysfunction in schizophrenia: evidence for compromised brain metabolism and oxidative stress. Mol Psychiatry. 2004, 9: 684-697.
Article
CAS
PubMed
Google Scholar
Arieti S: Heredity and constitution in schizophrenia. In Interpretation of Schizophrenia. 1974, London: Jason Aronson Inc, 441-451.
Google Scholar
Meltzer HY, Moline R: Muscle abnormalities in acute psychosis. Arch Gen Psychiatry. 1970, 23: 481-491. 10.1001/archpsyc.1970.01750060001001.
Article
CAS
PubMed
Google Scholar
Meltzer HY: Neuromuscular dysfunction in schizophrenia. Schizophr Bull. 1976, 2: 107-135.
Google Scholar
Fish B: Neurobiologic antecedents of schizophrenia in children. Arch Gen Psychiatry. 1977, 34: 1113-1118.
Article
Google Scholar
Cantor S, Trevenen C, Postuma R, Dueck R, Fjeldsted B: Is childhood schizophrenia a cholinergic disease?. Arch Gen Psychiatry. 1980, 37: 658-667. 10.1001/archpsyc.1980.01780190056007.
Article
CAS
PubMed
Google Scholar
Flyckt L, Borg J, Borg K, Ansved T, Edman G, Bjerkenstedt L, Wiesel FA: Muscle biopsy, macro EMG, and clinical characteristics in patients with schizophrenia. Biol Psychiatry. 2000, 47: 991-999. 10.1016/S0006-3223(99)00295-4.
Article
CAS
PubMed
Google Scholar
Kato T: The other, forgotten genome: mitochondrial DNA and mental disorders. Mol Psychiatry. 2001, 6: 625-633. 10.1038/sj.mp.4000926.
Article
CAS
PubMed
Google Scholar
Fattal O, Budur K, Vaughan AJ, Franco K: Review of the literature on major mental disorders in adult patients with mitochondrial diseases. Psychosomatics. 2006, 47: 1-7. 10.1176/appi.psy.47.1.1.
Article
PubMed
Google Scholar
Roubertoux PL, Sluyter F, Carlier M, Marcet B, Maarouf-Veray F, Chérif C, Marican C, Arrechi P, Godin F, Jamon M, Verrier B, Cohen-Salmon C: Mitochondrial DNA modifies cognition in interaction with the nuclear genome and age in mice. Nat Genet. 2003, 35: 65-69. 10.1038/ng1230.
Article
CAS
PubMed
Google Scholar
Seeman P: Dopamine receptors and the dopamine hypothesis of schizophrenia. Synapse. 1987, 1: 133-152. 10.1002/syn.890010203.
Article
CAS
PubMed
Google Scholar
Carlsson A: The current status of the dopamine hypothesis of schizophrenia. Neuropsychopharmacology. 1988, 1: 179-186. 10.1016/0893-133X(88)90012-7.
Article
CAS
PubMed
Google Scholar
Carlsson A, Hansson LO, Warters N, Carlsson ML: A glutamatergic deficiency model of schizophrenia. Br J Psychiatry. 1999, 37 (Suppl): 2-6.
Google Scholar
Laruelle M, Abi-Dargham A, Gil R, Kegeles L, Innis R: Increased dopamine transmission in schizophrenia: relationship to illness phase. Biol Psychiatry. 1999, 46: 56-72. 10.1016/S0006-3223(99)00067-0.
Article
CAS
PubMed
Google Scholar
Noh JS, Kim EY, Kang JS, Kim HR, Oh YJ, Gwag BJ: Neurotoxic and neuroprotective actions of catecholamines in cortical neurons. Exp Neurol. 1999, 159: 217-224. 10.1006/exnr.1999.7144.
Article
CAS
PubMed
Google Scholar
Friedhoff AJ: A dopamine-dependent restitutive system for the maintenance of mental normalcy. Ann NY Acad Sci. 1986, 463: 47-52. 10.1111/j.1749-6632.1986.tb21502.x.
Article
CAS
PubMed
Google Scholar
Davila R, Zumarraga M, Friedhoff AJ, Miller JC: Characteristics of the adaptive aspects of the dopamine system. Psychopharmacol Bull. 1988, 24: 338-340.
CAS
PubMed
Google Scholar
Friedhoff AJ, Simkowvitz P: A new conception of the relationship between psychological coping mechanisms and biological stress buffering systems. Br J Psychiatry. 1989, 154 (Suppl 4): 61-66.
Google Scholar
Bowers MB, Swigar ME, Jatlow PI, Goicoechea N: Plasma catecholamine metabolites and early response to haloperidol. J Clin Psychiatry. 1984, 45: 248-251.
PubMed
Google Scholar
Picker D, Labarca R: Neuroleptic-induced decrease in plasma homovanillic acid and antipsychotic activity in schizophrenic patients. Science. 1984, 225: 954-957. 10.1126/science.6474162.
Article
Google Scholar
Bowers MB, Swigar ME, Jatlow PI, Hoffman FJ: Plasma catecholamine metabolites and treatment response at neuroleptic steady state. Biol Psychiatry. 1989, 25: 734-738. 10.1016/0006-3223(89)90245-X.
Article
PubMed
Google Scholar
Arinami T, Itokawa M, Enguchi H, Tagaya H, Yano S, Shimizu H, Hamaguchi H, Toru M: Association of dopamine D2 receptor molecular variant with schizophrenia. Lancet. 1994, 343 (8899): 703-704. 10.1016/S0140-6736(94)91581-4.
Article
CAS
PubMed
Google Scholar
Itokawa M, Toru M, Ito K, Tsuga H, Kameyama K, Haga T, Arinami T, Hamaguchi H: Sequestration of the short and long isoforms of Dopamine D2 receptors expressed in Chinese hamster ovary cells. Mol Pharmacology. 1996, 49: 560-566.
CAS
Google Scholar
Ishige K, Chen Q, Sagara Y, Schubert D: The activation of dopamine D4 receptors inhibit oxidative stress-induced nerve cell death. J Neuroscience. 2001, 21: 6069-6076.
CAS
PubMed
Google Scholar
Sawada H, Ibi M, Kihara T, Urushitani M, Akaike A, Kimura J, Shimohama S: Dopamine D2-type agonist protect mesencephalic neurons from glutamate neurotoxicity: mechanism of neuroprotective treatment against oxidative stress. Ann Neurol. 1998, 44: 110-119. 10.1002/ana.410440117.
Article
CAS
PubMed
Google Scholar
Rosin C, Colombo S, Calver AA, Bates TE, Skaper SD: Dopamine D2 and D3 receptor agonist limits oligodendrocyte injury caused by glutamate oxidative stress and oxygen/glucose deprivation. Glia. 2005, 52: 336-343. 10.1002/glia.20250.
Article
PubMed
Google Scholar
Milusheva E, Baranyi M, Kittel A, Sperlagh B, Vizi ES: Increased sensitivity of striatal dopamine release to H2O2 upon chronic rotenone treatment. Free Radic Biol Med. 2005, 39: 133-142. 10.1016/j.freeradbiomed.2005.02.034.
Article
CAS
PubMed
Google Scholar
Snyder SH: Phencyclidine. Nature. 1980, 285: 335-336. 10.1038/285335a0.
Article
Google Scholar
Javitt DC, Zukin SR: Recent advances in the phencyclidine model of schizophrenia. Am J Psychiatry. 1991, 148: 1301-1308.
Article
CAS
PubMed
Google Scholar
Tamminga CA: Schizophrenia and glutamatergic transmission. Crit Rev Neurobiol. 1998, 12: 21-36. 10.1615/CritRevNeurobiol.v12.i1-2.20.
Article
CAS
PubMed
Google Scholar
Itil T, Keskiner A, Kiremitci N, Holden JMC: Effect of phencyclidine in chronic schizophrenics. Can J Psychiatry. 1967, 12: 209-212.
CAS
Google Scholar
Lahti AC, Koffel B, Laporte D, Tamminga CA: Subanesthetic doses of ketamine stimulate psychosis in schizophrenia. Neuropsychopharmacology. 1994, 13: 9-19.
Article
Google Scholar
Malhotra AK, Pinals DA, Adler CM, Elman I, Clifton A, Pickar D, Breier A: Ketamine-induced exacerbation of psychotic symptoms and cognitive impairment in neuroleptic-free schizophrenics. Neuropsychopharmacology. 1997, 17: 141-149. 10.1016/S0893-133X(97)00036-5.
Article
CAS
PubMed
Google Scholar
Behrens MM, Ali SS, Dao DN, Lucero J, Shekhtman G, Quick KL, Dugan LL: Ketamine-induced loss of phenotype of fast-spiking interneuron is mediated by NADPH-oxidase. Science. 2007, 318: 1645-1647. 10.1126/science.1148045.
Article
CAS
PubMed
Google Scholar
Goff DC, Coyle JT: The emerging role of glutamate in the pathophysiology and treatment of schizophrenia. Am J Psychiatry. 2001, 158: 1367-1377. 10.1176/appi.ajp.158.9.1367.
Article
CAS
PubMed
Google Scholar
Xia S, Cai ZY, Thio LL, Kim-Han JS, Dugan LL, Covey DF, Rothman SM: The estrogen receptor is not essential for all estrogen neuroprotection: new evidence from a new analog. Neurobiol Dis. 2002, 9: 282-293. 10.1006/nbdi.2002.0478.
Article
CAS
PubMed
Google Scholar
Zuo DY, Wu YL, Yao WX, Cao Y, Wu CF, Tanaka M: Effect of MK-801 and ketamine on hydroxyl radical generation in the posterior cingulated and retrosplenial cortex of free-moving mice, as determined by in vivo microdialysis. Pharmacol Biochem Behav. 2007, 86: 1-7. 10.1016/j.pbb.2006.05.010.
Article
CAS
PubMed
Google Scholar
Atlante A, Calissano P, Bobba A, Giannattasio S, Marra E, Passarella S: Glutamate neurotoxicity, oxidative stress and mitochondria. FEBS Lett. 2001, 497: 1-5. 10.1016/S0014-5793(01)02437-1.
Article
CAS
PubMed
Google Scholar
Marini AM, Paul SM: N-methyl-D-aspartate receptor-mediated neuroprotection in cerebellar granule cells requires new RNA and protein synthesis. Proc Natl Sci USA. 1992, 89: 6555-6559. 10.1073/pnas.89.14.6555.
Article
CAS
Google Scholar
Marini AM, Rabin SJ, Lipsky RH, Mocchetti I: Activity-dependent release of brain-derived neurotrophic factor underlies the neuroprotective effect of N-methyl-D-aspartate. J Biol Chem. 1998, 273: 29394-29399. 10.1074/jbc.273.45.29394.
Article
CAS
PubMed
Google Scholar
Bhave SV, Ghoda L, Hoffman PL: Brain-derived neurotrophic factor mediates the anti-apoptotic effect of NMDA in cerebellar granule neurons: signal transduction cascades and site of ethanol action. J Neurosci. 1999, 19: 3277-3286.
CAS
PubMed
Google Scholar
Xifró X, Falluel-Morel A, Miñano A, Aubert N, Fadó R, Malagelada C, Vaudry D, Vaudry H, Gonzalez B, Rodríguez-Alvarez J: N-methyl-D-aspartate blocks activation of JNK and mitochondrial apoptotic pathway induced by potassium deprivation in cerebellar granule cells. J Biol Chem. 2006, 281: 6801-6812. 10.1074/jbc.M504571200.
Article
PubMed
CAS
Google Scholar
Köhr G, Seeburg PH: Subtype-specific regulation of recombinant NMDA receptor-channels by protein tyrosine kinases of the src family. J Physiol. 1996, 492: 445-452.
Article
PubMed Central
PubMed
Google Scholar
Trotti D, Rizzini BL, Rossi D, Haugeto O, Danbolt NC, Volterra A: Neuronal and glial glutamate transporters possess an SH-based redox regulatory mechanism. Eur J Neurosci. 1997, 9: 1236-1243. 10.1111/j.1460-9568.1997.tb01478.x.
Article
CAS
PubMed
Google Scholar
Lipton SA, Choi YB, Takahashi H, Zhang D, Li W, Godzik A, Bankston LA: Cysteine regulation of protein function-as exemplified by NMDA-receptor modulation. Trends Neurosci. 2002, 25: 474-480. 10.1016/S0166-2236(02)02245-2.
Article
CAS
PubMed
Google Scholar
Mustafa AK, Kumar M, Selvakumar B, Ho GP, Ehmsen JT, Barrow RK, Amzel LM, Snyder SH: Nitric oxide S-nitrosylates serine racemase, mediating feedback inhibition of D-serine formation. Proc Natl Acad Sci USA. 2007, 104: 2950-2955. 10.1073/pnas.0611620104.
Article
PubMed Central
CAS
PubMed
Google Scholar
Papadia S, Soriano FX, Léveillé F, Martel MA, Dakin KA, Hansen HH, Kaindl A, Sifringer M, Fowler J, Stefovska V, McKenzie G, Craigon M, Corriveau R, Ghazal P, Horsburgh K, Yankner BA, Wyllie DJ, Ikonomidou C, Hardingham GE: Synaptic NMDAreceptor activity boosts intrinsic antioxidant defenses. Nat Neurosci. 2008, 11: 476-487. 10.1038/nn2071.
Article
PubMed Central
CAS
PubMed
Google Scholar
Arai M, Yuzawa H, Nohara I, Ohnishi T, Obata N, Iwayama Y, Haga S, Toyota T, Ujike H, Arai M, Ichikawa T, Nishida A, Tanaka Y, Furukawa A, Aikawa Y, Kuroda O, Niizato K, Izawa R, Hashimoto K, Iyo M, Sora I, Matsushita M, Okazaki Y, Yoshikawa T, Miyata T, Itokawa M: Enhanced carbonyl stress in a subpopulation of schizophrenia. Arch Gen Psychiatry. 2010, 67: 589-597. 10.1001/archgenpsychiatry.2010.62.
Article
CAS
PubMed
Google Scholar
Miyata T, Kurokawa K, De Strihou CVY: Advanced glycation and lipidoxidation end products: role of reactive carbonyl compounds generated during carbohydrate and lipid metabolism. J Am Nephrol. 2000, 11: 1744-1752.
CAS
Google Scholar
Shimizu A, Kurachi M, Yamaguchi N, Torii H, Isaki K: Morbidity risk of schizophrenia to parents and siblings of schizophrenic patients. Jpn J Psychiatry Neurol. 1987, 41: 65-71.
CAS
PubMed
Google Scholar
Goldstein JM, Faraone SV, Chen WJ, Tolomiczencko GS, Tsuang MT: Sex differences in the familial transmission of schizophrenia. Br J Psychiatry. 1990, 156: 819-826. 10.1192/bjp.156.6.819.
Article
CAS
PubMed
Google Scholar
Valero J, Martorell L, Marine J, Vilella E, Labad A: Anticipation and imprinting in Spanish families with schizophrenia. Acta Psychiatr Scand. 1998, 97: 343-350. 10.1111/j.1600-0447.1998.tb10013.x.
Article
CAS
PubMed
Google Scholar
Li X, Sundquist J, Sundquist K: Age-specific familial risks of psychotic disorders and schizophrenia: a nation-wide epidemiological study from Sweden. Schizophr Res. 2007, 97: 43-50. 10.1016/j.schres.2007.09.027.
Article
PubMed Central
PubMed
Google Scholar
Malaspina D, Harlap S, Fennig S, Heiman D, Nahon D, Feldman D, Susser ES: Advancing paternal age and the risk of schizophrenia. Arch Gen Psychiatry. 2001, 58: 361-367. 10.1001/archpsyc.58.4.361.
Article
CAS
PubMed
Google Scholar
Zammit S, Allebeck P, Dalman C, Lundberg I, Hemmingson T, Owen MJ, Lewis G: Paternal age and risk for schizophrenia. Brit J Psychiatry. 2003, 183: 405-408. 10.1192/bjp.183.5.405.
Article
Google Scholar
Byrne M, Agerbo E, Ewald H, Eaton WW, Mortensen PB: Parental age risk of schizophrenia. A case–control study. Arch Gen Psychiatry. 2003, 60: 673-678. 10.1001/archpsyc.60.7.673.
Article
PubMed
Google Scholar
El-Saadi O, Pedersen CB, McNeil TF, Saha S, Welham J, O'Callaghan E, Cantor-Graae E, Chant D, Mortensen PB, McGrath J: Paternal and maternal age as risk factors for psychosis: findings from Denmark, Sweden and Australia. Schizophr Res. 2004, 67: 227-236. 10.1016/S0920-9964(03)00100-2.
Article
PubMed
Google Scholar
Sipos A, Rasmussen F, Harrison G, Tynelius P, Lewis G, Leon DA, Gunnell D: Paternal age and schizophrenia; a population based cohort study. BMJ. 2004, 329: 1070-10.1136/bmj.38243.672396.55.
Article
PubMed Central
PubMed
Google Scholar
Gottesman II, Bertelsen A: Confirming unexpressed genotypes for schizophrenia. Risks in the offspring of Fischer’s Danish identical and fraternal discordant twins. Arch Gen Psychiatry. 1989, 46: 867-872. 10.1001/archpsyc.1989.01810100009002.
Article
CAS
PubMed
Google Scholar
Bakker SC, Hoogendoorn MLC, Selten J-P, Verdujin W, Pearson PL, Sinke RJ, Kahn RS: Neuregulin 1: genetic support for schizophrenia subtypes. Mol Psychiatry. 2004, 9: 1061-1063. 10.1038/sj.mp.4001564.
Article
CAS
PubMed
Google Scholar
Doi N, Usui C: Are ‘high-risk’ haplotypes in DTNBP1 and NRG1 resistance genes for schizophrenia?. Am J Psychiatry. 2006, 163: 940-941.
Article
PubMed
Google Scholar
Doi N, Itokawa M, Hoshi Y, Arai M, Furukawa A, Hiroshi Ujike, Sora I, Yoshikawa T: A resistance gene in disguise for schizophrenia?. Am J Med Genet Part B (Neuropsychiatric Genetics). 2007, 144B: 165-173. 10.1002/ajmg.b.30365.
Article
Google Scholar
Lo WS, Xu Z, Yu Z, Pun FW, Ng SK, Chen J, Tong KL, Zhao C, Xu X, Tsang SY, Harano M, Stöber G, Nimgaonkar VL, Xue H: Positive selection within the schizophrenia-associated GABAA receptor β2 gene. PLoS One. 2007, 2 (5): e462-10.1371/journal.pone.0000462.
Article
PubMed Central
PubMed
CAS
Google Scholar
Crepsi B, Summers K, Dorus S: Adaptive evolution of genes underlying schizophrenia. Proc R Soc B. 2007, 274: 2801-2810. 10.1098/rspb.2007.0876.
Article
CAS
Google Scholar
Kulkarni J, Fink G: Hormones and psychosis. Women and schizophrenia. Edited by: Castle DL, McGrath J, Kulkarni J. 2000, Cambridge: Cambridge University Press, 51-66.
Google Scholar
Goldstein JM, Lewine RRJ: Overview of sex differences in schizophrenia: where have we been and where do we go from?. Women and schizophrenia. Edited by: Castle DL, McGrath J, Kulkarni J. 2000, Cambridge: Cambridge University Press, 111-143.
Google Scholar
Behl C: Oestrogen as a neuroprotective hormone. Nat Rev Neurosci. 2002, 3: 433-442.
CAS
PubMed
Google Scholar
Strehlow K, Rotter S, Wassmann S, Adam O, Grohé C, Laufs K, Böhm M, Nickenig G: Modulation of antioxidant enzyme expression and function by estrogen. Circ Res. 2003, 93: 170-173. 10.1161/01.RES.0000082334.17947.11.
Article
CAS
PubMed
Google Scholar
Pajović SB, Saićić ZS, Spasić MB, Petrović VM: The effect of ovarian hormones on antioxidant enzyme activities in the brain of male rats. Physiol Res. 2003, 52: 189-194.
PubMed
Google Scholar
Brann DW, Dhandapani K, Wakade C, Mahesh VB, Khan M: Neurotrophic and neuroprotective actions of estrogen: basic mechanism and clinical implications. Steroids. 2007, 72: 381-405. 10.1016/j.steroids.2007.02.003.
Article
PubMed Central
CAS
PubMed
Google Scholar
Monje P, Boland R: Subcellular distribution of native estrogen receptor alpha and beta isoforms in rabbit uterus and ovary. J Cell Biochem. 2001, 82: 467-479. 10.1002/jcb.1182.
Article
CAS
PubMed
Google Scholar
Chen JQ, Delannoy M, Cooke C, Yager JD: Mitochondrial localization of ERalpha and ERbeta in human MCF7 cells. Am J Physiol. 2004, 286: E1011-E1022.
CAS
Google Scholar
Stirone C, Duckles SP, Krause DN, Procaccio V: Estrogen increases mitochondrial efficiency and reduces oxidative stress in cerebral blood vessels. Mol Pharmacol. 2005, 68: 959-965. 10.1124/mol.105.014662.
Article
CAS
PubMed
Google Scholar
Susser E, Neugebauer R, Hoek HW, Brown AS, Lin S, Labovitz D, Gorman JM: Schizophrenia after prenatal famine. Further evidence. Arch Gen Psychiatry. 1996, 53: 25-31. 10.1001/archpsyc.1996.01830010027005.
Article
CAS
PubMed
Google Scholar
Brown AS, Bottiglieri T, Schaefer CA, Quesenberry CP, Liu L, Bresnahan M, Susser ES: Elevated prenatal homocysteine levels as a risk factor for schizophrenia. Arch Gen Psychiatry. 2007, 64: 31-39. 10.1001/archpsyc.64.1.31.
Article
CAS
PubMed
Google Scholar
Opler MGA, Susser ES: Fetal environment and schizophrenia. Environment Health Perspectives. 2005, 113: 1239-1242. 10.1289/ehp.7572.
Article
CAS
Google Scholar
Limosin F, Rouillon F, Payan C, Cohen J-M, Strub N: Prenatal exposure to influenza as a risk factor for adult schizophrenia. Acta Psychiatr Scand. 2003, 107: 331-335. 10.1034/j.1600-0447.2003.00052.x.
Article
CAS
PubMed
Google Scholar
Brown AS, Begg MD, Gravenstein S, Schaefer CA, Wyatt RJ, Bresnahan M, Babulas VP, Susser ES: Serologic evidence of prenatal influenza in the etiology of schizophrenia. Arch Gen Psychiatry. 2004, 61: 774-780. 10.1001/archpsyc.61.8.774.
Article
PubMed
Google Scholar
Brown AS, Shaefer C, Quesenberry CP, Liu L, Babulas VP, Susser E: Maternal exposure to toxoplasmosis and risk of schizophrenia in adult offspring. Am J Psychiatry. 2005, 162: 767-773. 10.1176/appi.ajp.162.4.767.
Article
PubMed
Google Scholar
Dalman C, Allebeck P, Gunnell D, Harrison G, Kristensson K, Lewis G, Lofving S, Rasmussen F, Wicks S, Karlsson H: Infections in the CNS during childhood and the risk of subsequent psychotic illness: a cohort study of more than one million Swedish subjects. Am J Psychiatry. 2008, 165: 59-65.
Article
PubMed
Google Scholar
Akaike T, Ando M, Oda T, Doi T, Ijiri S, Araki S, Maeda H: Dependence on O2- generation by xanthine oxidase of pathogenesis of influenza infection in mice. J Clin Invest. 1990, 85: 739-745. 10.1172/JCI114499.
Article
PubMed Central
CAS
PubMed
Google Scholar
Buffinton GD, Christen S, Peterhans E, Stocker R: Oxidative stress in lungs of mice infected with influenza A virus. Free Radc Res Commun. 1992, 16: 99-110. 10.3109/10715769209049163.
Article
CAS
Google Scholar
Edlund C, Holemberg G, Dallnen G, Norrby E, Kristensson K: Ubiquinone-10 protect neurons from virus-induced degenerations. J Neurochem. 1994, 63: 634-639.
Article
CAS
PubMed
Google Scholar
Speir E, Yu ZX, Ferrans VJ, Huang ES, Epstein SE: Aspirin attenuates cytomegalovirus infectivity and gene expression mediated by cyclooxigenase-2 in coronary artery smooth muscle cells. Circ Res. 1998, 83: 210-216. 10.1161/01.RES.83.2.210.
Article
CAS
PubMed
Google Scholar
He L, Perkins GA, Poblenz AT, Harris JB, Hung M, Ellisman MH, Fox DA: Bcl-xL overexpression blocks bax-mediated mitochondrial contact site formation and apoptosis in rod photoreceptors of lead-exposed mice. Proc Natl Acd Sci USA. 2003, 100: 1022-1027. 10.1073/pnas.0333594100.
Article
CAS
Google Scholar
Berger MM, Jia XY, Legay V, Aymard M, Tilles JG, Lina B: Nutrition- and virus-induced stress repress the expression of manganese superoxide dismutase in vitro. Exp Biol Med. 2004, 229: 843-849.
CAS
Google Scholar
Gupta P, Narang M, Banerjee BD, Basu S: Oxidative stress in term small for gestational age neonates born to undernourished mothers: a case controlled study. BMC Pediatr. 2004, 4: 14-20. 10.1186/1471-2431-4-14.
Article
PubMed Central
PubMed
Google Scholar
Zaki MH, Akutu T, Akaike T: Nitric oxide-induced nitrative stress involved in microbial pathogenesis. J Pharmacol Sci. 2005, 98: 117-129. 10.1254/jphs.CRJ05004X.
Article
CAS
PubMed
Google Scholar
Kruman II, Culmsee C, Chan SL, Kruman Y, Guo Z, Penix L, Mattson MP: Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity. J Neurosci. 2000, 20: 6920-6026.
CAS
PubMed
Google Scholar
Wang J, Wu J, Zhang Z: Oxidative stress in mouse brain exposed to lead. Ann Occup Hyg. 2006, 50: 405-409. 10.1093/annhyg/mei079.
Article
CAS
PubMed
Google Scholar
Poncet D, Pauleau AL, Szabadkai G, Vozza A, Scholz SR, Le Bras M, Brière JJ, Jalil A, Le Moigne R, Brenner C, Hahn G, Wittig I, Schägger H, Lemaire C, Bianchi K, Souquère S, Pierron G, Rustin P, Goldmacher VS, Rizzuto R, Palmieri F, Kroemer G: Cytopathic effects of cytomegalovirus-encoded apoptosis inhibitory protein vMIA. J Cell Biol. 2006, 174: 985-996. 10.1083/jcb.200604069.
Article
PubMed Central
CAS
PubMed
Google Scholar
Chang CM, Yu CC, Lu HT, Chou YF, Huang RF: Folate deprivation promotes mitochondrial oxidative decay : DNA large deletions, cytochrome c oxidase dysfunction, membrane depolarisation and superoxide overproduction in rat liver. Br J Nutr. 2007, 97: 855-863. 10.1017/S0007114507666410.
Article
CAS
PubMed
Google Scholar
Nishikawa Y, Kawase O, Vielemeyer O, Suzuki H, Joiner KA, Xuan X, Nagasawa H: Toxoplasma gondii infection induces apoptosis in noninfected macrophages: role of nitric oxide and other soluble factors. Parasite Immunol. 2007, 29: 375-385. 10.1111/j.1365-3024.2007.00956.x.
Article
CAS
PubMed
Google Scholar
Shanklin DR, Sibai BM: Ultrastructural aspects of preeclampsia. II. Mitochondrial changes. Am J Obstet Gynecol. 1990, 163: 943-953.
Article
CAS
PubMed
Google Scholar
Barton JR, Hiett AK, O’Connor WM, Nissen SE, Greene JW: Endomyocardial ultrastructural findings in preeclampsia. Am J Obstet Gynecol. 1991, 165: 389-391.
Article
CAS
PubMed
Google Scholar
Furui T, Kurauchi O, Tanaka M, Mizutani S, Ozawa T, Tomoda Y: Decrease in cytochrome c oxidase and cytochrome oxidase subunit I messenger RNA levels in preeclamptic pregnancies. Obstet Gynecol. 1994, 84: 283-288.
CAS
PubMed
Google Scholar
Torbergsen T, Oian P, Mathiesen E, Borud O: Pre-eclampsia - A mitochondrial disease?. Acta Obstet Gynecol Scand. 1989, 68: 145-148. 10.3109/00016348909009902.
Article
CAS
PubMed
Google Scholar
Folgero T, Storbakk N, Torbergsen T, Oian P: Mutations in mitochondrial transfer ribonucleic acid genes in preeclampsia. Am J Obstet Gynecol. 1996, 174: 1626-1630. 10.1016/S0002-9378(96)70619-1.
Article
CAS
PubMed
Google Scholar
Dalman C, Allebeck P, Cullberg J, Grunewald C, Köster M: Obstetric complications and the risk of schizophrenia. A longitudinal study of a national birth cohort. Arch Gen Psychiatry. 1999, 56: 234-240.
CAS
PubMed
Google Scholar
Cannon M, Jones PB, Murray RM: Obstetric complications and schizophrenia: historical and meta-analytic review. Am J Psychiatry. 2002, 159: 1080-1092. 10.1176/appi.ajp.159.7.1080.
Article
PubMed
Google Scholar
Rapoport JL, Addington AM, Fragnau S: The neurodevelopmental model of schizophrenia: update 2005. Mol Psychiatry. 2005, 10: 434-449. 10.1038/sj.mp.4001642.
Article
CAS
PubMed
Google Scholar
Sobel D: Infant malformations and mortality in children of schizophrenic parents. Psychiatr Q. 1961, 35: 60-64. 10.1007/BF01572557.
Article
Google Scholar
Rieder RQ, Rosenthal D, Wender P, Blumenthal H: The offspring of schizophrenics, I: fetal and neonatal deaths. Arch Gen Psychiatry. 1975, 32: 200-211. 10.1001/archpsyc.1975.01760200064006.
Article
CAS
PubMed
Google Scholar
Modrzewska K: The offspring of schizophrenic parents in a North Swedish isolate. Clin Genet. 1980, 17: 191-201.
Article
CAS
PubMed
Google Scholar
Hitchon CA, El-Gabalawy HS: Oxidation in rheumatoid arthritis. Arthritis Res Ther. 2004, 6: 265-278. 10.1186/ar1447.
Article
PubMed Central
PubMed
Google Scholar
Remans PH, van Oosterhout M, Smeets TJ, Sanders M, Frederiks WM, Reedquist KA, Tak PP, Breedveld FC, van Laar JM: Intracellular free radical production in synovial T lymphocytes from patients with rheumatoid arthritis. Arthritis Rheum. 2005, 52: 2003-2009. 10.1002/art.21111.
Article
CAS
PubMed
Google Scholar
Vinogradov S, Gottesman II, Moises HW, Nicol S: Negative association between schizophrenia and rheumatoid arthritis. Schizophr Bull. 1991, 17: 669-678.
Article
CAS
PubMed
Google Scholar
Rubinstein G: Schizophrenia, rheumatoid arthritis and natural resistance genes. Schizophr Res. 1997, 25: 177-181. 10.1016/S0920-9964(97)00023-6.
Article
CAS
PubMed
Google Scholar
Oken RJ, Schulzer M: At issue: schizophrenia and rheumatoid arthritis: the negative association revised. Schizophr Bull. 1999, 25: 625-638. 10.1093/oxfordjournals.schbul.a033407.
Article
CAS
PubMed
Google Scholar
Samper E, Nicholls DG, Melov S: Mitochondrial oxidative stress causes chromosomal instability of mouse embryonic fibroblasts. Aging Cell. 2003, 2: 277-285. 10.1046/j.1474-9728.2003.00062.x.
Article
CAS
PubMed
Google Scholar
Ragu S, Faye G, Iraqui I, Masurel-Heneman A, Kolodner RD, Huang M-E: Oxygen metabolism and reactive oxygen species cause chromosomal rearrangements and cell death. Proc Natl Acad Sci USA. 2007, 104: 9747-9752. 10.1073/pnas.0703192104.
Article
PubMed Central
CAS
PubMed
Google Scholar
Macintyre DJ, Blackwood DHR, Porteous DJ, Pickard BS, Muir WJ: Chromosomal abnormalities and mental illness. Mol Psychiatry. 2003, 8: 275-287. 10.1038/sj.mp.4001232.
Article
CAS
PubMed
Google Scholar
Pulver AE, Nestadt G, Goldberg R, Shprintzen RJ, Lamacz M, Wolyniec PS, Morrow B, Karayiorgou M, Antonarakis SE, Housman D: Psychotic illness in patients diagnosed with velo-cardio-facial syndrome and their relatives. J Nerv Ment Dis. 1994, 182: 476-478. 10.1097/00005053-199408000-00010.
Article
CAS
PubMed
Google Scholar
Murphy KC, Jones LA, Owen MJ: High rates of schizophrenia in adults with velo-cardio-facial syndrome. Arch Gen Psychiatry. 1999, 56: 940-945. 10.1001/archpsyc.56.10.940.
Article
CAS
PubMed
Google Scholar
Walsh T, McClellan JM, McCarthy SE, Addington AM, Pierce SB, Copper GM, Nord AS, Kusenda M, Malhortra D, Bhandari A, Stray SM, Rippery CF, Roccanova P, Makarov V, Lakshmi B, Finling RL, Sikich L, Stromerg T, Merriman B, Gogtay N, Butler P, Eckstrand K, Noory L, Gochman P, Long R, Chen Z, Davis S, Baker C, Eichler EE, Meltzer PS, Nelson SF, Singleton AB, Lee MK, Rapoport JL, King MC, Sebat J: Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia. Science. 2008, 320: 539-543. 10.1126/science.1155174.
Article
CAS
PubMed
Google Scholar
Xu B, Roos JL, Levy S, van Rensburg EJ, Gogos JA, Karayiorgou M: Strong association of de novo copy number mutations with sporadic schizophrenia. Nat Genet. 2008, 40: 880-885. 10.1038/ng.162.
Article
CAS
PubMed
Google Scholar
Awadalla P, Gauthier J, Myers RA, Casals F, Hamdan FF, Griffing AR, Côté M, Henrion E, Spiegelman D, Tarabeux J, Piton A, Yang Y, Boyko A, Bustamante C, Xiong L, Rapoport JL, Addington AM, DeLisi JLE, Krebs M-O, Joober R, Millet B, Fombonne É, Mottron L, Zilversmit M, Keebler J, Daoud H, Marineau C, Roy-Gagnon M-H, Dubé M-P, Eyre-Walker A, Drapeau P, Stone EA, Lafrenière RG, Rouleau GA: Direct measure of the de novo mutation rate in autism and schizophrenia cohorts. Am J Hum Genet. 2010, 87: 316-324. 10.1016/j.ajhg.2010.07.019.
Article
PubMed Central
CAS
PubMed
Google Scholar
Smith CL, Bolton A, Nguyen G: Genomic and epigenomic instability, fragile sites, schizophrenia and autism. Current Genomics. 2010, 11: 447-469. 10.2174/138920210793176001.
Article
PubMed Central
CAS
PubMed
Google Scholar
Demirhan O, Tastemir D, Sertdemir Y: Chromosomal fragile sites in schizophrenic patients. Genetika. 2006, 42: 985-992.
CAS
PubMed
Google Scholar
Ohsawa I, Ishikawa M, Takahashi K, Watanabe M, Nishimaki K, Yamagata K, Katsura K, Katayama Y, Asoh S, Ohta S: Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med. 2007, 13: 688-694. 10.1038/nm1577.
Article
CAS
PubMed
Google Scholar
Lindholm E, Cavelier L, Howell WM, Eriksson I, Jalonen P, Adolfsson R, Blackwood DH, Muir WJ, Brookes AJ, Gyllensten U, Jazin EE: Mitochondrial sequence variants in patients with schizophrenia. Eur J Hum Genet. 1997, 5: 406-412.
CAS
PubMed
Google Scholar
Marchbanks RM, Ryan M, Day IN, Owen M, McGuffin P, Whatley SA: A mitochondrial DNA sequence variant associated with schizophrenia and oxidative stress. Schizophr Res. 2003, 65: 33-38. 10.1016/S0920-9964(03)00011-2.
Article
CAS
PubMed
Google Scholar
Martorell L, Segués T, Folch G, Valero J, Joven J, Labad A, Vilella E: New variants in the mitochondrial genomes of schizophrenic patients. Eur J Hum Genet. 2006, 14: 520-528. 10.1038/sj.ejhg.5201606.
Article
CAS
PubMed
Google Scholar
Bamne MN, Talkowski ME, Moraes CT, Manuck SB, Ferrell RE, Chowdari KV, Nimgaonkar VL: Systematic association studies of mitochondrial DNA variations in schizophrenia: focus on the ND5 gene. Schizophr Bull. 2008, 34: 458-465.
Article
PubMed Central
PubMed
Google Scholar
Rollins B, Martin MV, Sequeira PA, Moon EA, Morgan LZ, Watson SJ, Schatzberg A, Akil H, Myers RM, Jones EG, Wallace DC, Bunney WE, Vawter MP: Mitochondrial variants in schizophrenia, bipolar disorder, and major depressive disorder. PLoS One. 2009, 4 (3): e4913-10.1371/journal.pone.0004913.
Article
PubMed Central
PubMed
CAS
Google Scholar
Ueno H, Nishigaki Y, Kong QP, Fuku N, Kojima S, Iwata N, Ozaki N, Tanaka M: Analysis of mitochondrial DNA variants in Japanese patients with schizophrenia. Mitochondrion. 2009, 9: 385-393. 10.1016/j.mito.2009.06.003.
Article
CAS
PubMed
Google Scholar
Ichikawa T, Arai M, Miyashita M, Arai M, Obata N, Nohara I, Oshima K, Niizato K, Okazaki Y, Doi N, Itokawa M: Schizophrenia: maternal inheritance and heteroplasmy of mtDNA mutations. Mol Genet Metab. 2012, 105: 103-109. 10.1016/j.ymgme.2011.09.034.
Article
CAS
PubMed
Google Scholar
Pulkes T, Hanna MG: Clinical aspects of mitochondrial encephalomyopathies. Genetics of mitochondrial diseases. Edited by: Holt IJ. 2003, New York: Oxford University Press, 87-109.
Google Scholar
Bertolin C, Magri C, Barlati S, Vettori A, Perini GI, Peruzzi P, Mostacciuolo ML, Vazza G: Analysis of complete mitochondrial genomes of patients with schizophrenia and bipolar disorder. J Hum Genet. 2011, 56: 869-872. 10.1038/jhg.2011.111.
Article
CAS
PubMed
Google Scholar
Sue CM, Quigley A, Katsabanis S, Kapsa R, Crimmins DS, Byrne E, Morris JGL: Detection of MELAS A3243G point mutation in muscle, blood and hair follicles. J Neurol Sci. 1998, 161: 36-39. 10.1016/S0022-510X(98)00179-8.
Article
CAS
PubMed
Google Scholar
Risch N, Reich EW, Wishnick MM, McCarthy JG: Spontaneous mutation and parental age in humans. Am J Hum Genet. 1987, 41: 218-248.
PubMed Central
CAS
PubMed
Google Scholar
Ohashi J, Tokunaga K: The expected power of genome-wide linkage disequilibrium testing using single nucleotide polymorphism markers for detecting a low-frequency disease variant. Ann Hum Genet. 2002, 66: 297-306. 10.1046/j.1469-1809.2002.00119.x.
Article
CAS
PubMed
Google Scholar