Carlborg A, Winnerbäck K, Jönsson EG, Jokinen J, Nordström P: Suicide in schizophrenia. Expert Rev Neurother. 2010, 10: 1153-1164. 10.1586/ern.10.82.
Article
PubMed
Google Scholar
Hor K, Taylor M: Suicide and schizophrenia: a systematic review of rates and risk factors. J Psychopharmacol. 2010, 24: 81-90. 10.1177/1359786810385490.
Article
PubMed Central
PubMed
Google Scholar
Pompili M, Amador XF, Girardi P, Harkavy-Friedman J, Harrow M, Kaplan K, Krausz M, Lester D, Meltzer HY, Modestin J: Suicide risk in schizophrenia: learning from the past to change the future. Ann Gen Psychiatry. 2007, 6: 10-10.1186/1744-859X-6-10.
Article
PubMed Central
PubMed
Google Scholar
Glowinski AL, Bucholz KK, Nelson EC, Fu Q, Madden PA, Reich W, Heath AC: Suicide attempts in an adolescent female twin sample. J Am Acad Child Adolesc Psychiatry. 2001, 40: 1300-1307. 10.1097/00004583-200111000-00010.
Article
PubMed Central
CAS
PubMed
Google Scholar
Statham DJ, Heath AC, Madden PA, Bucholz KK, Bierut L, Dinwiddie SH, Slutske WS, Dunne MP, Martin NG: Suicidal behaviour: an epidemiological and genetic study. Psychol Med. 1998, 28: 839-855. 10.1017/S0033291798006916.
Article
CAS
PubMed
Google Scholar
Willour VL, Seifuddin F, Mahon PB, Jancic D, Pirooznia M, Steele J, Schweizer B, Goes FS, Mondimore FM, Mackinnon DF: A genome-wide association study of attempted suicide. Mol Psychiatry. 2011,:-
Google Scholar
Gingrich JA, Ansorge MS, Merker R, Weisstaub N, Zhou M: New lessons from knockout mice: The role of serotonin during development and its possible contribution to the origins of neuropsychiatric disorders. CNS Spectr. 2003, 8: 572-577.
PubMed
Google Scholar
Manuck SB, Flory JD, McCaffery JM, Matthews KA, Mann JJ, Muldoon MF: Aggression, impulsivity, and central nervous system serotonergic responsivity in a nonpatient sample. Neuropsychopharmacology. 1998, 19: 287-299.
Article
CAS
PubMed
Google Scholar
Neumeister A: Tryptophan depletion, serotonin, and depression: where do we stand?. Psychopharmacol Bull. 2003, 37: 99-115.
PubMed
Google Scholar
Neumeister A, Nugent AC, Waldeck T, Geraci M, Schwarz M, Bonne O, Bain EE, Luckenbaugh DA, Herscovitch P, Charney DS, Drevets WC: Neural and behavioral responses to tryptophan depletion in unmedicated patients with remitted major depressive disorder and controls. Arch Gen Psychiatry. 2004, 61: 765-773. 10.1001/archpsyc.61.8.765.
Article
CAS
PubMed
Google Scholar
Li D, He L: Meta-analysis supports association between serotonin transporter (5-HTT) and suicidal behavior. Mol Psychiatry. 2007, 12: 47-54. 10.1038/sj.mp.4001890.
Article
PubMed
CAS
Google Scholar
Lin PY, Tsai G: Association between serotonin transporter gene promoter polymorphism and suicide: results of a meta-analysis. Biol Psychiatry. 2004, 55: 1023-1030. 10.1016/j.biopsych.2004.02.006.
Article
CAS
PubMed
Google Scholar
Mann JJ: Neurobiology of suicidal behaviour. Nat Rev Neurosci. 2003, 4: 819-828.
Article
CAS
PubMed
Google Scholar
Stanley M, Mann JJ: Increased serotonin-2 binding sites in frontal cortex of suicide victims. Lancet. 1983, 1: 214-216.
Article
CAS
PubMed
Google Scholar
Stanley M, Virgilio J, Gershon S: Tritiated imipramine binding sites are decreased in the frontal cortex of suicides. Science. 1982, 216: 1337-1339. 10.1126/science.7079769.
Article
CAS
PubMed
Google Scholar
Mann JJ, Huang YY, Underwood MD, Kassir SA, Oppenheim S, Kelly TM, Dwork AJ, Arango V: A serotonin transporter gene promoter polymorphism (5-HTTLPR) and prefrontal cortical binding in major depression and suicide. Arch Gen Psychiatry. 2000, 57: 729-738. 10.1001/archpsyc.57.8.729.
Article
CAS
PubMed
Google Scholar
Courtet P, Jollant F, Castelnau D, Buresi C, Malafosse A: Suicidal behavior: relationship between phenotype and serotonergic genotype. Am J Med Genet C Semin Med Genet. 2005, 133C: 25-33. 10.1002/ajmg.c.30043.
Article
PubMed
Google Scholar
Bellivier F, Chaste P, Malafosse A: Association between the TPH gene A218C polymorphism and suicidal behavior: a meta-analysis. Am J Med Genet B Neuropsychiatr Genet. 2004, 124B: 87-91. 10.1002/ajmg.b.20015.
Article
PubMed
Google Scholar
Rujescu D, Giegling I, Sato T, Hartmann AM, Moller HJ: Genetic variations in tryptophan hydroxylase in suicidal behavior: analysis and meta-analysis. Biol Psychiatry. 2003, 54: 465-473. 10.1016/S0006-3223(02)01748-1.
Article
CAS
PubMed
Google Scholar
Saetre P, Lundmark P, Wang A, Hansen T, Rasmussen HB, Djurovic S, Melle I, Andreassen OA, Werge T, Agartz I: The tryptophan hydroxylase 1 (TPH1) gene, schizophrenia susceptibility, and suicidal behavior: a multi-centre case–control study and meta-analysis. Am J Med Genet B Neuropsychiatr Genet. 2009, 153B: 387-396.
Google Scholar
Anguelova M, Benkelfat C, Turecki G: A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: II. Suicidal behavior. Mol Psychiatry. 2003, 8: 646-653.
Article
CAS
PubMed
Google Scholar
Holmes A, Lit Q, Murphy DL, Gold E, Crawley JN: Abnormal anxiety-related behavior in serotonin transporter null mutant mice: the influence of genetic background. Genes Brain Behav. 2003, 2: 365-380. 10.1046/j.1601-1848.2003.00050.x.
Article
CAS
PubMed
Google Scholar
Holmes A, Murphy DL, Crawley JN: Abnormal behavioral phenotypes of serotonin transporter knockout mice: parallels with human anxiety and depression. Biol Psychiatry. 2003, 54: 953-959. 10.1016/j.biopsych.2003.09.003.
Article
CAS
PubMed
Google Scholar
Hariri AR, Drabant EM, Weinberger DR: Imaging genetics: perspectives from studies of genetically driven variation in serotonin function and corticolimbic affective processing. Biol Psychiatry. 2006, 59: 888-897. 10.1016/j.biopsych.2005.11.005.
Article
CAS
PubMed
Google Scholar
Cheng R, Juo SH, Loth JE, Nee J, Iossifov I, Blumenthal R, Sharpe L, Kanyas K, Lerer B, Lilliston B: Genome-wide linkage scan in a large bipolar disorder sample from the National Institute of Mental Health genetics initiative suggests putative loci for bipolar disorder, psychosis, suicide, and panic disorder. Mol Psychiatry. 2006, 11: 252-260. 10.1038/sj.mp.4001778.
Article
CAS
PubMed
Google Scholar
Hesselbrock V, Dick D, Hesselbrock M, Foroud T, Schuckit M, Edenberg H, Bucholz K, Kramer J, Reich T, Goate A: The search for genetic risk factors associated with suicidal behavior. Alcohol Clin Exp Res. 2004, 28: 70S-76S.
Article
PubMed
Google Scholar
Willour VL, Zandi PP, Badner JA, Steele J, Miao K, Lopez V, MacKinnon DF, Mondimore FM, Schweizer B, McInnis MG: Attempted suicide in bipolar disorder pedigrees: evidence for linkage to 2p12. Biol Psychiatry. 2007, 61: 725-727. 10.1016/j.biopsych.2006.05.014.
Article
CAS
PubMed
Google Scholar
Zubenko GS, Maher BS, Hughes HB, Zubenko WN, Scott Stiffler J, Marazita ML: Genome-wide linkage survey for genetic loci that affect the risk of suicide attempts in families with recurrent, early-onset, major depression. Am J Med Genet B Neuropsychiatr Genet. 2004, 129: 47-54.
Article
Google Scholar
Butler AW, Breen G, Tozzi F, Craddock N, Gill M, Korszun A, Maier W, Middleton LT, Mors O, Owen MJ: A genomewide linkage study on suicidality in major depressive disorder confirms evidence for linkage to 2p12. Am J Med Genet B Neuropsychiatr Genet. 2010, 153: 1465-1473.
Article
Google Scholar
Hansen T, Olsen L, Lindow M, Jakobsen KD, Ullum H, Jonsson E, Andreassen OA, Djurovic S, Melle I, Agartz I: Brain expressed microRNAs implicated in schizophrenia etiology. PLoS One. 2007, 2: e873-10.1371/journal.pone.0000873.
Article
PubMed Central
PubMed
CAS
Google Scholar
Jönsson EG, Larsson K, Vares M, Hansen T, Wang AG, Djurovic S, Rönningen KS, Andreassen OA, Agartz I, Werge T: Two methylenetetrahydrofolate reductase gene (MTHFR) polymorphisms, schizophrenia and bipolar disorder: an association study. Am J Med Genet B Neuropsychiatr Genet. 2008, 147B: 976-982. 10.1002/ajmg.b.30671.
Article
PubMed
Google Scholar
Kähler AK, Djurovic S, Kulle B, Jönsson EG, Agartz I, Hall H, Opjordsmoen S, Jakobsen KD, Hansen T, Melle I: Association analysis of schizophrenia on 18 genes involved in neuronal migration: MDGA1 as a new susceptibility gene. Am J Med Genet B Neuropsychiatr Genet. 2008, 147B: 1089-1100. 10.1002/ajmg.b.30726.
Article
PubMed
Google Scholar
Saetre P, Agartz I, De Franciscis A, Lundmark P, Djurovic S, Kähler A, Andreassen OA, Jakobsen KD, Rasmussen HB, Werge T: Association between a disrupted-in-schizophrenia 1 (DISC1) single nucleotide polymorphism and schizophrenia in a combined Scandinavian case–control sample. Schizophr Res. 2008, 106: 237-241. 10.1016/j.schres.2008.08.024.
Article
PubMed
Google Scholar
Wigginton JE, Abecasis GR: PEDSTATS: descriptive statistics, graphics and quality assessment for gene mapping data. Bioinformatics. 2005, 21: 3445-3447. 10.1093/bioinformatics/bti529.
Article
CAS
PubMed
Google Scholar
Gabriel SB, Schaffner SF, Nguyen H, Moore JM, Roy J, Blumenstiel B, Higgins J, DeFelice M, Lochner A, Faggart M: The structure of haplotype blocks in the human genome. Science. 2002, 296: 2225-2229. 10.1126/science.1069424.
Article
CAS
PubMed
Google Scholar
Barrett JC, Fry B, Maller J, Daly MJ: Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics. 2005, 21: 263-265. 10.1093/bioinformatics/bth457.
Article
CAS
PubMed
Google Scholar
Dudbridge F: Pedigree disequilibrium tests for multilocus haplotypes. Genet Epidemiol. 2003, 25: 115-121. 10.1002/gepi.10252.
Article
PubMed
Google Scholar
Dudbridge F: Likelihood-based association analysis for nuclear families and unrelated subjects with missing genotype data. Hum Hered. 2008, 66: 87-98. 10.1159/000119108.
Article
PubMed Central
PubMed
Google Scholar
De Luca V, Zai G, Tharmalingam S, de Bartolomeis A, Wong G, Kennedy JL: Association study between the novel functional polymorphism of the serotonin transporter gene and suicidal behaviour in schizophrenia. Eur Neuropsychopharmacol. 2006, 16: 268-271. 10.1016/j.euroneuro.2005.09.007.
Article
CAS
PubMed
Google Scholar
Dubertret C, Hanoun N, Ades J, Hamon M, Gorwood P: Family-based association study of the 5-HT transporter gene and schizophrenia. Int J Neuropsychopharmacol. 2005, 8: 87-92. 10.1017/S1461145704004948.
Article
CAS
PubMed
Google Scholar
Lin C, Tang W, Hu J, Gao L, Huang K, Xu Y, He G, Liang P, Feng G, He L, Shi Y: Haplotype analysis confirms association of the serotonin transporter (5-HTT) gene with schizophrenia in the Han Chinese population. Neurosci Lett. 2009, 453: 210-213. 10.1016/j.neulet.2009.02.023.
Article
CAS
PubMed
Google Scholar
Saiz PA, Garcia-Portilla MP, Arango C, Morales B, Alvarez V, Coto E, Fernandez JM, Bascaran MT, Bousono M, Bobes J: Association study of serotonin 2A receptor (5-HT2A) and serotonin transporter (5-HTT) gene polymorphisms with schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2007, 31: 741-745. 10.1016/j.pnpbp.2007.01.012.
Article
CAS
PubMed
Google Scholar
Vijayan NN, Iwayama Y, Koshy LV, Natarajan C, Nair C, Allencherry PM, Yoshikawa T, Banerjee M: Evidence of association of serotonin transporter gene polymorphisms with schizophrenia in a South Indian population. J Hum Genet. 2009, 54: 538-542. 10.1038/jhg.2009.76.
Article
CAS
PubMed
Google Scholar
Zaboli G, Jonsson EG, Gizatullin R, De Franciscis A, Asberg M, Leopardi R: Haplotype analysis confirms association of the serotonin transporter (5-HTT) gene with schizophrenia but not with major depression. Am J Med Genet B Neuropsychiatr Genet. 2008, 147: 301-307.
Article
PubMed
CAS
Google Scholar
Tsai SJ, Hong CJ, Liou YJ: Recent molecular genetic studies and methodological issues in suicide research. Prog Neuropsychopharmacol Biol Psychiatry. 2011, 35: 809-817. 10.1016/j.pnpbp.2010.10.014.
Article
CAS
PubMed
Google Scholar
Arango V, Huang YY, Underwood MD, Mann JJ: Genetics of the serotonergic system in suicidal behavior. J Psychiatr Res. 2003, 37: 375-386. 10.1016/S0022-3956(03)00048-7.
Article
PubMed
Google Scholar
Gonda X, Fountoulakis KN, Harro J, Pompili M, Akiskal HS, Bagdy G, Rihmer Z: The possible contributory role of the S allele of 5-HTTLPR in the emergence of suicidality. J Psychopharmacol. 2011, 25: 857-866. 10.1177/0269881110376693.
Article
CAS
PubMed
Google Scholar
Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, Benjamin J, Muller CR, Hamer DH, Murphy DL: Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science. 1996, 274: 1527-1531. 10.1126/science.274.5292.1527.
Article
CAS
PubMed
Google Scholar
Hu XZ, Lipsky RH, Zhu G, Akhtar LA, Taubman J, Greenberg BD, Xu K, Arnold PD, Richter MA, Kennedy JL: Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder. Am J Hum Genet. 2006, 78: 815-826. 10.1086/503850.
Article
PubMed Central
CAS
PubMed
Google Scholar
Martin J, Cleak J, Willis-Owen SA, Flint J, Shifman S: Mapping regulatory variants for the serotonin transporter gene based on allelic expression imbalance. Mol Psychiatry. 2007, 12: 421-422. 10.1038/sj.mp.4001952.
Article
CAS
PubMed
Google Scholar
Levinson DF: Meta-analysis in psychiatric genetics. Curr Psychiatry Rep. 2005, 7: 143-151. 10.1007/s11920-005-0012-9.
Article
PubMed
Google Scholar
Furlong RA, Ho L, Walsh C, Rubinsztein JS, Jain S, Paykel ES, Easton DF, Rubinsztein DC: Analysis and meta-analysis of two serotonin transporter gene polymorphisms in bipolar and unipolar affective disorders. Am J Med Genet. 1998, 81: 58-63. 10.1002/(SICI)1096-8628(19980207)81:1<58::AID-AJMG11>3.0.CO;2-V.
Article
CAS
PubMed
Google Scholar
Lotrich FE, Pollock BG: Meta-analysis of serotonin transporter polymorphisms and affective disorders. Psychiatr Genet. 2004, 14: 121-129. 10.1097/00041444-200409000-00001.
Article
PubMed
Google Scholar
Lasky-Su JA, Faraone SV, Glatt SJ, Tsuang MT: Meta-analysis of the association between two polymorphisms in the serotonin transporter gene and affective disorders. Am J Med Genet B Neuropsychiatr Genet. 2005, 133B: 110-115. 10.1002/ajmg.b.30104.
Article
PubMed
Google Scholar
Cho HJ, Meira-Lima I, Cordeiro Q, Michelon L, Sham P, Vallada H, Collier DA: Population-based and family-based studies on the serotonin transporter gene polymorphisms and bipolar disorder: a systematic review and meta-analysis. Mol Psychiatry. 2005, 10: 771-781. 10.1038/sj.mp.4001663.
Article
CAS
PubMed
Google Scholar
McEachin RC, Saccone NL, Saccone SF, Kleyman-Smith YD, Kar T, Kare RK, Ade AS, Sartor MA, Cavalcoli JD, McInnis MG: Modeling complex genetic and environmental influences on comorbid bipolar disorder with tobacco use disorder. BMC Med Genet. 2010, 11: 14-
Article
PubMed Central
CAS
PubMed
Google Scholar
Feinn R, Nellissery M, Kranzler HR: Meta-analysis of the association of a functional serotonin transporter promoter polymorphism with alcohol dependence. Am J Med Genet B Neuropsychiatr Genet. 2005, 133B: 79-84. 10.1002/ajmg.b.30132.
Article
PubMed
Google Scholar
McHugh RK, Hofmann SG, Asnaani A, Sawyer AT, Otto MW: The serotonin transporter gene and risk for alcohol dependence: a meta-analytic review. Drug Alcohol Depend. 2010, 108: 1-6. 10.1016/j.drugalcdep.2009.11.017.
Article
PubMed Central
CAS
PubMed
Google Scholar
Lopez-Leon S, Janssens AC, Gonzalez-Zuloeta Ladd AM, Del-Favero J, Claes SJ, Oostra BA, van Duijn CM: Meta-analyses of genetic studies on major depressive disorder. Mol Psychiatry. 2008, 13: 772-785. 10.1038/sj.mp.4002088.
Article
CAS
PubMed
Google Scholar
Clarke H, Flint J, Attwood AS, Munafo MR: Association of the 5- HTTLPR genotype and unipolar depression: a meta-analysis. Psychol Med. 2010, 40: 1767-1778. 10.1017/S0033291710000516.
Article
CAS
PubMed
Google Scholar
Daray FM, Thommi SB, Ghaemi SN: The pharmacogenetics of antidepressant-induced mania: a systematic review and meta-analysis. Bipolar Disord. 2010, 12: 702-706. 10.1111/j.1399-5618.2010.00864.x.
Article
PubMed
Google Scholar
Biernacka JM, McElroy SL, Crow S, Sharp A, Benitez J, Veldic M, Kung S, Cunningham JM, Post RM, Mrazek D, Frye MA: Pharmacogenomics of antidepressant induced mania: a review and meta-analysis of the serotonin transporter gene (5HTTLPR) association. J Affect Disord. 2012, 136: e21-29. 10.1016/j.jad.2011.05.038.
Article
CAS
PubMed
Google Scholar
Karg K, Burmeister M, Shedden K, Sen S: The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: evidence of genetic moderation. Arch Gen Psychiatry. 2011, 68: 444-454. 10.1001/archgenpsychiatry.2010.189.
Article
PubMed Central
PubMed
Google Scholar
Risch N, Herrell R, Lehner T, Liang KY, Eaves L, Hoh J, Griem A, Kovacs M, Ott J, Merikangas KR: Interaction Between the Serotonin Transporter Gene (5-HTTLPR), Stressful Life Events, and Risk of Depression A Meta-analysis. Jama-Journal of the American Medical Association. 2009, 301: 2462-2471. 10.1001/jama.2009.878.
Article
CAS
Google Scholar
Schinka JA, Busch RM, Robichaux-Keene N: A meta-analysis of the association between the serotonin transporter gene polymorphism (5-HTTLPR) and trait anxiety. Mol Psychiatry. 2004, 9: 197-202. 10.1038/sj.mp.4001405.
Article
CAS
PubMed
Google Scholar
Sen S, Burmeister M, Ghosh D: Meta-analysis of the association between a serotonin transporter promoter polymorphism (5-HTTLPR) and anxiety-related personality traits. Am J Med Genet B Neuropsychiatr Genet. 2004, 127B: 85-89. 10.1002/ajmg.b.20158.
Article
PubMed
Google Scholar
Munafo MR, Freimer NB, Ng W, Ophoff R, Veijola J, Miettunen J, Jarvelin MR, Taanila A, Flint J: 5-HTTLPR genotype and anxiety-related personality traits: a meta-analysis and new data. Am J Med Genet B Neuropsychiatr Genet. 2009, 150B: 271-281. 10.1002/ajmg.b.30808.
Article
PubMed Central
PubMed
Google Scholar
Fan JB, Sklar P: Meta-analysis reveals association between serotonin transporter gene STin2 VNTR polymorphism and schizophrenia. Mol Psychiatry. 2005, 10: 928-938. 10.1038/sj.mp.4001690.
Article
CAS
PubMed
Google Scholar
Allen NC, Bagade S, McQueen MB, Ioannidis JP, Kavvoura FK, Khoury MJ, Tanzi RE, Bertram L: Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. Nat Genet. 2008, 40: 827-834. 10.1038/ng.171.
Article
CAS
PubMed
Google Scholar
Shi J, Gershon ES, Liu C: Genetic associations with schizophrenia: meta-analyses of 12 candidate genes. Schizophr Res. 2008, 104: 96-107. 10.1016/j.schres.2008.06.016.
Article
PubMed Central
PubMed
Google Scholar
Rao D, Jönsson EG, Paus S, Ganguli R, Nöthen M, Nimgaonkar VL: Schizophrenia and the serotonin transporter gene. Psychiatr Genet. 1998, 8: 207-212. 10.1097/00041444-199808040-00002.
Article
CAS
PubMed
Google Scholar
Wendland JR, Moya PR, Kruse MR, Ren-Patterson RF, Jensen CL, Timpano KR, Murphy DL: A novel, putative gain-of-function haplotype at SLC6A4 associates with obsessive-compulsive disorder. Hum Mol Genet. 2008, 17: 717-723.
Article
CAS
PubMed
Google Scholar
Morey RA, Hariri AR, Gold AL, Hauser MA, Munger HJ, Dolcos F, McCarthy G: Serotonin transporter gene polymorphisms and brain function during emotional distraction from cognitive processing in posttraumatic stress disorder. BMC Psychiatry. 2011, 11: 76-10.1186/1471-244X-11-76.
Article
PubMed Central
CAS
PubMed
Google Scholar
Diaconu G, Turecki G: Obsessive-compulsive personality disorder and suicidal behavior: evidence for a positive association in a sample of depressed patients. J Clin Psychiatry. 2009, 70: 1551-1556. 10.4088/JCP.08m04636.
Article
PubMed
Google Scholar
Panagioti M, Gooding P, Tarrier N: Post-traumatic stress disorder and suicidal behavior: A narrative review. Clin Psychol Rev. 2009, 29: 471-482. 10.1016/j.cpr.2009.05.001.
Article
PubMed
Google Scholar
Jönsson EG, Saetre P, Vares M, Andreou D, Larsson K, Timm S, Rasmussen HB, Djurovic S, Melle I, Andreassen OA: DTNBP1, NRG1, DAOA, DAO and GRM3 polymorphisms and schizophrenia: an association study. Neuropsychobiology. 2009, 59: 142-150. 10.1159/000218076.
Article
PubMed
CAS
Google Scholar