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Neurobiology of brain disorders

  1. Power spectral analysis (PSA) is one of the most commonly-used EEG markers of cortical hyperarousal, and can help to understand subjective–objective sleep discrepancy (SOD). Age is associated with decreased sl...

    Authors: Biyun Xu, Qinghao Cai, Runru Mai, Hailong Liang, Jiayu Huang and Zhimin Yang
    Citation: Behavioral and Brain Functions 2022 18:2
  2. Schizophrenia research arose in the twentieth century and is currently rapidly developing, focusing on many parallel research pathways and evaluating various concepts of disease etiology. Today, we have relati...

    Authors: Enrico Patrono, Jan Svoboda and Aleš Stuchlík
    Citation: Behavioral and Brain Functions 2021 17:7
  3. Aging is the leading risk factor for several age-associated diseases such as neurodegenerative diseases. Understanding the biology of aging mechanisms is essential to the pursuit of brain health. In this regar...

    Authors: Aliabbas Zia, Ali Mohammad Pourbagher-Shahri, Tahereh Farkhondeh and Saeed Samarghandian
    Citation: Behavioral and Brain Functions 2021 17:6
  4. Obsessive–compulsive disorder (OCD) is a mental disease with heterogeneous behavioral phenotypes, including repetitive behaviors, anxiety, and impairments in cognitive functions. The brain regions related to t...

    Authors: Xiao Chen, Jihui Yue, Yuchong Luo, Lianyan Huang, Boxing Li and Shenglin Wen
    Citation: Behavioral and Brain Functions 2021 17:4
  5. Middle-aged females, especially perimenopausal females, are vulnerable to depression, but the potential mechanism remains unclear. Dopaminergic and GABAergic system dysfunction is involved in the pathophysiolo...

    Authors: Guofen Cao, Gaili Meng, Li Zhu, Jie Zhu, Nan Dong, Xiaolan Zhou, Sumei Zhang and Yongai Zhang
    Citation: Behavioral and Brain Functions 2021 17:2
  6. Parkinson's disease (PD) is a common neurodegenerative disorder characterized by progressive loss of nigrostriatal dopaminergic neurons leading to dopamine depletion and problems of movement, emotions, and cog...

    Authors: Dina M. Monir, Motamed E. Mahmoud, Omyma G. Ahmed, Ibrahim F. Rehan and Amany Abdelrahman
    Citation: Behavioral and Brain Functions 2020 16:9
  7. Maternal immune activation (MIA) during gestation can increase the later risk of schizophrenia in adult offspring. Neuroinflammation is believed to underlie this process. Postmortem brain studies have found ch...

    Authors: Shuang Ding, Yunqing Hu, Binbin Luo, Yaqi Cai, Keke Hao, Yongfeng Yang, Yan Zhang, Xiujuan Wang, Minli Ding, Hongxing Zhang, Wenqiang Li and Luxian Lv
    Citation: Behavioral and Brain Functions 2019 15:3
  8. Signs of pervasive developmental disorder and social deficits were reported in toddlers and children whose mothers were exposed to organophosphate pesticides during pregnancy. Deficits in social preference wer...

    Authors: Anat Lan, Daniel Stein, Miguel Portillo, Debra Toiber and Ora Kofman
    Citation: Behavioral and Brain Functions 2019 15:2
  9. Narcolepsy is a chronic sleep disorder characterized by excessive daytime sleepiness, cataplexy, hypnagogic hallucinations, and sleep paralysis. This disease affects significantly the overall patient functioni...

    Authors: C. Schiappa, S. Scarpelli, A. D’Atri, M. Gorgoni and Luigi De Gennaro
    Citation: Behavioral and Brain Functions 2018 14:19
  10. Schizophrenia (SZ) is a complex polygenic psychiatric disorder caused in part by abnormal dopamine levels. Cerebral dopamine neurotrophic factor (CDNF) 2 is known to protect and repair the dopaminergic system. Do...

    Authors: Yongfeng Yang, Hongyan Yu, Wenqiang Li, Bing Liu, Hongxing Zhang, Shuang Ding, Yanli Lu, Tianzi Jiang and Luxian Lv
    Citation: Behavioral and Brain Functions 2018 14:1
  11. Olfaction is often affected in parkinsonian patients, but dopaminergic cells in the olfactory bulb are not affected by some Parkinson-inducing drugs. We investigated whether the drug MPTP produces the olfactor...

    Authors: Carla Mucignat and Antonio Caretta
    Citation: Behavioral and Brain Functions 2017 13:1
  12. Attention deficit hyperactivity disorder (ADHD) is a prevalent and multifactorial neuropsychiatric disorder in the human population worldwide. Complex etiology and clinical heterogeneity have challenged the re...

    Authors: Jenni Puurunen, Sini Sulkama, Katriina Tiira, Cesar Araujo, Marko Lehtonen, Kati Hanhineva and Hannes Lohi
    Citation: Behavioral and Brain Functions 2016 12:27
  13. To reduce the number of patients with depression, biomarkers for clarifying psychiatric disorders are warranted. Numerous candidates have been proposed; however, near-infrared spectroscopy (NIRS) with multi-ch...

    Authors: Shinya Kinoshita, Tetsufumi Kanazawa, Hiroki Kikuyama and Hiroshi Yoneda
    Citation: Behavioral and Brain Functions 2016 12:25
  14. We investigated whether variation in the dopamine D2 receptor gene (DRD2) and tri-dimensional personality questionnaire (TPQ) scores could be used to aid adjustment of daily methadone requirements of heroin addic...

    Authors: Min-Wei Huang, Tai-An Chiang, Pei-Yu Lo and Ching-Shan Huang
    Citation: Behavioral and Brain Functions 2016 12:24
  15. Cancer diagnosis is associated with an increased suicide risk, particularly within the first 1 year after diagnosis of cancer. Abnormal function of the hypothalamic–pituitary–adrenal axis has been implicated i...

    Authors: Subin Park, Jin Pyo Hong, Jong-Keuk Lee, Young-Mi Park, Yangsoon Park, Juri Jeon, Myeong Hee Ahn and Se Chang Yoon
    Citation: Behavioral and Brain Functions 2016 12:22
  16. As the prevalence of autism spectrum disorders in people with epilepsy ranges from 15 to 47 % (Clarke et al. in Epilepsia 46:1970–1977, 2005), it is speculated that there is a special relationship between the two...

    Authors: Chanyoung Ko, Namwook Kim, Eunjoo Kim, Dong Ho Song and Keun-Ah Cheon
    Citation: Behavioral and Brain Functions 2016 12:20
  17. Whereas acute nicotine administration alters brain function which may, in turn, contribute to enhanced attention and performance, chronic cigarette smoking is linked with regional brain atrophy and poorer cogn...

    Authors: Matthew T. Sutherland, Michael C. Riedel, Jessica S. Flannery, Julio A. Yanes, Peter T. Fox, Elliot A. Stein and Angela R. Laird
    Citation: Behavioral and Brain Functions 2016 12:16
  18. Potassium bromate (KBrO3) is widely used as a food additive and is a major water disinfection by-product. The present study reports the side effects of KBrO3 administration on the brain functions and behaviour of...

    Authors: Jamaan Ajarem, Naif G. Altoom, Ahmed A. Allam, Saleh N. Maodaa, Mostafa A. Abdel- Maksoud and Billy KC. Chow
    Citation: Behavioral and Brain Functions 2016 12:14
  19. Anxieties, such as shyness, noise phobia and separation anxiety, are common but poorly understood behavioural problems in domestic dogs, Canis familiaris. Although studies have demonstrated genetic and environmen...

    Authors: Jenni Puurunen, Katriina Tiira, Marko Lehtonen, Kati Hanhineva and Hannes Lohi
    Citation: Behavioral and Brain Functions 2016 12:7
  20. Parsley was employed as an experimental probe to prevent the behavioral, biochemical and morphological changes in the brain tissue of the albino mice following chronic cadmium (Cd) administration.

    Authors: Saleh N. Maodaa, Ahmed A. Allam, Jamaan Ajarem, Mostafa A. Abdel-Maksoud, Gadah I. Al-Basher and Zun Yao Wang
    Citation: Behavioral and Brain Functions 2016 12:6
  21. Autism spectrum disorder (ASD) refers to a broad spectrum of neurodevelopmental disorders characterized by three central behavioral symptoms: impaired social interaction, impaired social communication, and res...

    Authors: Hyopil Kim, Chae-Seok Lim and Bong-Kiun Kaang
    Citation: Behavioral and Brain Functions 2016 12:3
  22. To investigate the effects of microglia/macrophages activation induced by intrastriatal thrombin injection on dentate gyrus neurogenesis and spatial memory ability in mice.

    Authors: Yuan Yang, Meikui Zhang, Xiaoni Kang, Chen Jiang, Huan Zhang, Pei Wang and Jingjing Li
    Citation: Behavioral and Brain Functions 2015 11:30
  23. High-mobility group box 1 (HMGB1) was observed to be an important extracellular mediator involved in vascular inflammation associated with subarachnoid hemorrhage (SAH). This study is of interest to examine th...

    Authors: Chih-Zen Chang, Shu-Chuan Wu, Aij-Lie Kwan and Chih-Lung Lin
    Citation: Behavioral and Brain Functions 2015 11:28